Articles
A Novel Capsule Coating Process For The Application Of Enteric Coatings To Small Batch Sizes
April 29, 2009
•Application Note: A Novel Capsule Coating Process For The Application Of Enteric Coatings To Small Batch Sizes
By GEA Process Engineering Inc.
As a pharmaceutical solid dosage form, hard gelatin capsules offer several advantages over traditional tablets. They can be filled with any combination of granules, powders, liquids, semi-solid formulations, and mini-tablets. Capsules require fewer manufacturing steps to produce, which reduces the amount of equipment needed. Capsules are also easy to swallow, mask tastes and odors, and may be easier to differentiate than tablets.
Enteric film coating is used to stabilize a drug in the gastrointestinal tract such that it can pass through the stomach and dissolve in the small intestine . Enteric coated hard gelatin capsules combine the advantages of the delivery system with the protective properties of the film coating. However, the physicochemical properties of the capsule shell present significant challenges when film coating hard gelatin capsules with enteric polymers.
The inherent flexibility and presence of residual moisture in the capsule shell present problems when coating capsules with conventional coating equipment such as a side-vented pan coater. In addition, either atmospheric moisture or the drug may permeate into the capsule shell, or volatile components in the capsule shell may escape into the atmosphere or permeate into the drug .
Click Here To Download:•Application Note: A Novel Capsule Coating Process For The Application Of Enteric Coatings To Small Batch Sizes
GEA Process Engineering Inc. • 9165 Rumsey Road • Columbia, MD 21045
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