Articles
RSSBi-Layer Tablets — Why Special Technology Is Required
August 7, 2008
•White Paper: Bi-Layer Tablets — Why Special Technology Is Required
By GEA Process Engineering
Several pharmaceutical companies are currently developing bi-layer tablets. For a variety of reasons: patent extension, therapeutic, marketing to name a few. To reduce capital investment, quite often existing but modified tablet presses are used to develop and produce such tablets. This article explains why the development and production of quality bi-layer tablets needs to be carried out on purpose-built tablet presses to overcome common bi-layer problems, such as layer--separation, insufficient hardness, inaccurate individual layer weight control, cross-contamination between the layers, reduced yield, etc. Using a modified tablet press may therefore not be your best approach to producing a quality bi-layer tablet under GMP-conditions. Especially when in addition high production output is required.
To produce a quality bi-layer tablet, in a validated and GMP-way, it is important that the selected press is capable of:
- Preventing capping and separation of the two individual layers that constitute the bi-layer tablet
- Providing sufficient tablet hardness
- Preventing cross-contamination between the two layers
- Producing a clear visual separation between the two layers
- High yield
- Accurate and individual weight control of the two layers
•White Paper: Bi-Layer Tablets — Why Special Technology Is Required
GEA Process Engineering Inc. • 9165 Rumsey Road • Columbia, MD 21045
Tel. 410-997-8700 • E-mail: info@niroinc.com • Website: www.niroinc.com
