Capturing Very Large Biomolecules With Membrane Chromatography

April 27, 2007

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•Article: Capturing Very Large Biomolecules With Membrane Chromatography

Manufacturing genetic therapies requires processing highly purified DNA/plasmid preparations that are free of contaminating proteins, viruses, nucleic acids, enzymes, and enzyme inhibitors. Quick methods for separating and purifying high–molecular-weight proteins and genetic vector preparations are essential to meet those needs. Traditional chromatography presents a number of inefficiencies with such large target molecules and slow diffusional flow rates. Here is a closer look at the enabling technology offered by ion-exchange membrane chromatography for purification. It offers the potential to significantly accelerate cycle times and help manufacturers bring new therapies to market faster.

Reprinted with permission from BioProcess International 3(10):58-59 (November 2005)

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•Article: Capturing Very Large Biomolecules With Membrane Chromatography

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