Articles
RSSMixed-Mode Sorbents
May 29, 2007
Click Here To Download:•Article: Mixed-Mode Sorbents
Biotech drug manufacturers have made many improvements to upstream protein production, such as cell-line engineering and adaptation to serum-free media, but the resulting greater yields have created challenges for downstream purification processes. To prevent process bottlenecks, the choice of chromatography method is critical. This advisor takes a look at new "mixed-mode" chromatography sorbents that combine hydrophobic and ionic components, making them useful for a number of approaches to protein purification. Unlike many sorbents used in hydrophobic-interaction chromatography, they need not be used with significant quantities of salt additives. That potentially increases the efficiency of purification processes while reducing costs and the environmental impact of salt disposal.
Meeting The Challenge
To meet a growing demand for protein-based therapies, biotech manufacturers have adopted new technologies that improve upstream biopharmaceutical production. But those improvements create challenges for downstream purification processes: more biomass leads to more product, often at higher concentrations, that needs to be purified.
•Article: Mixed-Mode Sorbents
SOURCE: Pall Life Sciences
