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02.26.09 -- Pfizer Discontinues Development Of Two Phase 3 Compounds

February 26, 2009

Pharmaceutical Online Newsletter
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Sponsored by: Catalent Pharma Solutions

In This Issue:

Industry News Articles Spotlight Downloads Products Multimedia Industry Events

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Catalent Pharma Solutions   Catalent Pharma Solutions is a leading provider of advanced dose form and packaging technologies as well as development, manufacturing and packaging services for pharmaceutical, biotechnology and consumer health companies. Catalent applies its local market expertise and technical creativity to advance treatments, change markets and enhance patient outcomes.
Download the Catalent Pharma Solutions company capabilities brochure for more information.

Featured Articles

Formulation Optimization
By Dr. Jeffrey Reingold, Manager, Contract Pharmacal Corp.
New products. New formulas. New hurdles. Whether it is determining the optimal thickness at a given run weight, or adjusting excipients to provide controlled release, there are a myriad of variables to consider when taking on a new drug product. What are the barriers to entry? Is the delivery system appropriate for the product? What type of packaging system is needed? What testing methods are required?


Achieving Optimal Particle Size Distribution In Inhalation Therapy
By Bob Bruno, Microfluidics
Inhalation therapy has proven to be an effective method of administering a number of pharmaceuticals for more than a century. However, achieving the optimal particle size for a treatment with particular pharmaceutical formulations has been a troublesome task. This article addresses many of the concerns that medical device manufacturers and their pharmaceutical partners have when attempting to achieve the correct particle size for an inhalation device.


Getting Ready To Purchase A New Mixer? Tips On How To Justify The Capital Expenditure
By Charles Ross & Son Company
Purchase of new mixing equipment is typically not a hasty event. Unless an unexpected challenge abruptly hit your operations such as a sudden failure of an existing mixer or a right-now sales opportunity demanding an unprecedented spike in production, process engineers generally have time to prepare for what could be a serious expenditure. As with any capital investment, the purchase of a new mixing system ideally requires time and research.


The Advantages Of Using An Electronically Commutated Motor (ECM) In Biosafety Cabinets
By Jim Hunter and Mike Rouse, Labconco Corporation
The modern Class II Biosafety Cabinet (BSC) was developed in the early 1960s as a result of the increased availability of High Efficiency Particulate Air (HEPA) filter technology. At the time, the motor of choice to drive the cabinet's blower was the Permanent Split Capacitor (PSC) type. The PSC motor, which is an alternating current (AC) motor, offered manufacturers an inexpensive power source whose speed could be electronically controlled to allow for airflow adjustment as the HEPA filter(s) loaded.


Particle Size Analysis Of Liposomes
By HORIBA Instruments, Inc.
Liposomes are bilayer vesicles made of phospholipids derived from natural or man-made materials mainly used for treatment of cancers as carriers of chemotherapeutic drugs to the tumor area. The amount of drug loaded into the liposomes and the size of the liposomes play pivotal roles in the pharmacokinetic and pharmacodynamic parameters of the drug. Hence accurate and rapid measurement of the size of liposomes is essential for novel and effective drug delivery systems.

Spotlight On Contract Services

Product Brochure: Encompass Analytical Services
Encompass Pharmaceutical Services extensive pharmaceutical experience provides for regulatory GMP/ICH/USP compliance along with scientific excellence. We bring you results with interpretation and direction to ensure your project's successful completion.

Product Brochure: Encompass Analytical Services

Datasheet: Refurbishing Program
INTERPHEX Booth 1141
Sharpsville Container Corp. offers services for refurbishment of stainless steel tanks and pressure vessels as well as transport containers at our facility. This service is a container refurbishing program to restore your equipment to "like new" condition.

Datasheet: Refurbishing Program

Company Brochure: American College Of Radiology (ACR) Image Metrix
With American College of Radiology (ACR) Image Metrix as your imaging partner you have the industry leader in imaging trial design, techniques and data extraction, and analysis. Based on your compound or device, ACR Image Metrix provides you with subspecialty imaging expertise specific to your clinical trial.

Company Brochure: American College Of Radiology (ACR) Image Metrix

ICON Insight: Imaging And Cardiology
By Jonathan Goldman, M.D., FACC, Chief Medical Officer, ICON Medical Imaging
Imaging has an increasing role in the evaluation of cardiac safety where it is used together with adverse events, ECG, and laboratory tests for cardiac enzymes to assess for cardiac toxicity. This is most often found where animal studies suggest possible signal for safety concern, or where cardiac toxicity is a known class effect for toxicity.

ICON Insight: Imaging And Cardiology

Datasheet: Active Pharmaceutical Ingredient (API) Capabilities
Aptuit offers a wide range of API services on a global scale. These services span the range of radiolabeled API for preclinical ADME work to commercial production of API post-NDA approval.

Datasheet: Active Pharmaceutical Ingredient (API) Capabilities

Product Sheet: Complex Sterile Manufacturing — World-Class Network
Pfizer CentreSource brings together the people and technologies you need to efficiently manufacture your sterile products. Pfizer's advanced technology infrastructure and regulatory compliance record combine to offer you a reliable global manufacturing source.

Product Sheet: Complex Sterile Manufacturing — World-Class Network

Featured Downloads

Brochure: Filter Housings
INTERPHEX Booth 2051
Allegheny Bradford provides filter housings for virtually every filter type, size and system. Our line of Universal housings combines the best features of the finest stainless steel filter housings with a full range of custom options that let us match your specifications quickly and affordably.


Product Catalog: Wallet Technology
Harro Höfliger Packaging Systems has been providing its customers with real wallet technology know-how for more than 25 years. From production of the blisters through to end packing of the products — with Höfliger you get all processes from one single source.


Brochure: CULEX-L Large Animal Automated In Vivo Sampling System
Collecting biofluid samples or physiological and behavioral data from animals presents challenges. To reduce the impact of manual sampling and provide more PK/PD data, BASi developed the Culex system for automated blood sampling in rodents. Since the pig is increasingly recommended in PK/PD and toxicology studies for its similarities to humans, we scaled the technology in the Culex system to the pig.


Product Sheet: Norwich Laboratory Services
Norwich Pharmaceuticals provides a wide range of laboratory support services, such as stability evaluation, microbiological testing, analytical testing and method development.

Browse the download library

Featured News

FDA Takes New Regulatory Action Against Ranbaxy's Paonta Sahib Plant
Genentech Rejects Roche's Latest Takeover Bid
Newly Discovered Antibodies May Lead To Lifelong Flu Vaccine
Pfizer Discontinues Development Of Two Phase 3 Compounds
Market For Niche Blockbusters Holds Promise For Large Pharmaceutical Companies
Merck Sells Glaucoma Product Line To Aton Pharma
Basilea Pharmaceutica Files Claims Against Johnson & Johnson
New GPC/SEC System Enables Rapid Analysis Proteins, Biopolymers
AstraZeneca To Participate In Tentative FDA Psychopharmacologic Drugs Advisory Committee
Use of Digital Signatures in Biopharmaceutical Industry Increased in 2008
Packaging Line Serialization Solution Gains SAP Certification
2009 Drug Pipeline Report: At Least 360 Protein Kinase Inhibitors In Active Development
INTERPHEX PharmaMedDevice Symposium To Focus On Convergence Of Pharma, Biologic Industries
USP Announces New Standards To Better Secure U.S. Drug Supply
Report: Pharmaceutical Pricing Has Become Key Driver In Lifecycle Management
View more headlines

Featured Multimedia

Video: TVIS-EX3 Tablet Visual Inspection System
Video: TVIS-EX3 Tablet Visual Inspection System
The TVIS-EX3 is a high-precision, powerful inspection system. The unique round-belt suction transfer mechanism firmly fixes tablets on the belt while keeping the tablets intact and the latest image processing technology enables detection of a 50 um square or larger black speck on tablets.

Bulletin Board


X-Ray Inspection Technology On-Demand Webcast

Join Ray Spurgeon, product manager, Eriez X-Ray Division, as he discusses how X-Ray inspection technology works, what the technology can do, as well as safety and regulatory concerns.

Industry Events

Writing In The Regulated Environment When English Is Your Second Language
February 26 and 27 | Malvern, PA

Stability Programs For Product Shelf Life: From Development To Approval
March 2 and 3 | Malvern, PA

Qualification And Calibration Of Quality Control Laboratory Instrumentation And Systems
March 4 and 5 | Malvern, PA

Pittcon 2009
March 8-13 | Chicago, IL

PTX South | Powder & Bulks Solids Southeast
March 11-12 | Charlotte, NC

INTERPHEX 2009
March 17-19 | New York, NY

LogiPharma Europe 2009
April 21-23 | Geneva, Switzerland

Submission Information

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Computrac MAX 5000XL Moisture Analyzer
Computrac MAX 5000XL Moisture Analyzer

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Blow-Fill-Seal bottelpack type 321M
Blow-Fill-Seal bottelpack type 321M

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INTERPHEX Booth 548

Non-Destructive Leak Testing For Filled And Sealed Pouches
Non-Destructive Leak Testing For Filled And Sealed Pouches

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INTERPHEX Booth 236

Tablex MC Metal Detector
Tablex MC Metal Detector

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INTERPHEX Booth 2737

TVIS-AS-C6 Tablet Visual Inspection System, Batch Saver
TVIS-AS-C6 Tablet Visual Inspection System, Batch Saver

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Manufacturing
Manufacturing

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CentronSQL Environmental Monitoring System
CentronSQL Environmental Monitoring System

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MiniModule Degasifier
MiniModule Degasifier

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Mastersizer 2000 Particle Size Analyzer
Mastersizer 2000 Particle Size Analyzer

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M 47 Rotary Filling And Capping Monobloc
M 47 Rotary Filling And Capping Monobloc

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INTERPHEX Booth 2277

2009 Workshops Pharma Polymers
2009 Workshops Pharma Polymers

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Design/Consulting
Design/Consulting

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INTERPHEX Booth 1273

Multi-Angle Light Scattering System- Calypso Composition Gradient
Multi-Angle Light Scattering System

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Pittcon Booth 4386

Contract Manufacturing-Encapsulation Services
Contract Manufacturing-Encapsulation Services

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Steril400 - Sterile Liquid Filler
Steril400 - Sterile Liquid Filler

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Formulation For Contract Manufacturing
Formulation For Contract Manufacturing

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XE3 Checkweigher
XE3 Checkweigher

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VAC-U-MAX Capsule/Tablet Conveyor
VAC-U-MAX Capsule/Tablet Conveyor

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Manual Disintegration Testing
Manual Disintegration Testing

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GMX Series: High Shear Granulator Mixers
GMX Series: High Shear Granulator Mixers

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