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RSSScale-Up From Laboratory To Production-Scale Spray Dryer
January 24, 2007
•Case Study: Scale-Up From Laboratory To Production-Scale Spray Dryer
Problem:
A pharmaceutical company uses various Spraying Systems Co. air atomizing nozzles in a laboratory-scale spray dryer for a proprietary coating application. The process in the laboratory spray dryer was optimized to achieve the desired product quality. The customer wanted to determine what nozzles would be needed to scale-up from the laboratory-scale spray dryer to a production spray dryer. It was important for the nozzles to produce a similar drop size distribution in the production spray dryer while increasing the overall product throughput by a factor of three to four times. Maintaining the drop size distribution in the scale-up is important to ensure consistent product quality.
Objective:
Experimentally obtain baseline spray characteristics and optimize the production-scale spray nozzle to meet these conditions. Provide optimized fluid conditions and spray characteristics designated by the laboratory-scale parameters required for production-scale spray dryers.
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•Case Study: Scale-Up From Laboratory To Production-Scale Spray Dryer
