News | April 16, 2008

LSM 710 Laser Scanning Microscope From Carl Zeiss Offers Sensitivity And Flexibility In One System

Carl Zeiss MicroImaging Inc., a leading provider of microscopy solutions for a variety of research, clinical and industrial applications, introduces the LSM 710 Laser Scanning Microscope. With the LSM 710 Laser Scanning Microscope, Carl Zeiss defines new standards for sensitivity and flexibility in examining fluorescent biological specimens.

This is a further milestone which Carl Zeiss is setting in its "Sound of Science" market launch campaign. Much like the breakthroughs achieved in music by advances in musical instrument design, the technical innovations of the LSM 710 provide new possibilities in research conducted with living, multi-labeled cells. With increased sensitivity, a higher signal-to-noise ratio, improved flexibility for new fluorescence dyes and multimodal experiments, as well as new multiphoton detectors for deeper optical penetration into biological structures, the system can give new impetus to all areas of biological research. Further hallmarks of the LSM 710 are its unique precision and reproducibility as well as its markedly easier operation.

Numerous technological innovations in the optical and electronic design as well as the software architecture of the LSM 710 allow for easier, faster and more efficient confocal fluorescence microscopy. The system's outstanding sensitivity ensures high-contrast, detailed images of even the most complex specimens, such as thick, living tissue samples. The new illumination and detection design provides absolute freedom in the selection and simultaneous imaging of up to ten fluorescence signals.

The basis is a filter-free spectral detection unit, which can be continuously set over the entire wavelength range, for the simultaneous imaging of up to 10 dyes. Innovative analysis methods such as integrated image correlation spectroscopy make it possible to extract quantitative information about molecule concentrations and mobility directly from the confocal images recorded.

Further benefits of the LSM 710 include the PTC laser design, which no longer requires a laser module and enables flexible combinations and fast upgrading of various lasers from near UV to the IR range. The innovative TwinGate main beam splitter concept supports up to 50 laser line combinations, features individually exchangeable filters and offers unparalleled suppression of the excitation laser light for brilliant, high-contrast images. The new QUASAR detector, configured with 2, 3 or 34 channels, is more sensitive and flexible than any previous detector system and offers spectral resolution of up to 3 nm. A spectral recycling loop increases the efficiency of the spectral splitting of fluorescence light emitted by the sample to almost 100%.

Automated software tools for system calibration and the control of the central performance parameters are always available to users and ensure that the LSM 710 operates in the optimum performance range at all times.

The Smart setup function of the ZEN 2008 software, a tool for dye-centered instrument configuration, is another system highlight which makes image acquisition faster and easier than ever before.

The LSM 710 Laser Scanning Microscope can be combined with upright and inverted Axio microscope stands from Carl Zeiss. For more information on the LSM 710 please visit www.zeiss.de/.

About Carl Zeiss MicroImaging, Inc.
Carl Zeiss MicroImaging, Inc., a subsidiary of Carl Zeiss, Inc., offers microscopy solutions and systems for research, laboratories, routine and industrial applications. In addition, Carl Zeiss MicroImaging markets microscopy and digital pathology systems for the clinical market, as well as spectral sensors for industrial and pharmaceutical applications.

Since1846, Carl Zeiss has remained committed to enabling science and technology to go beyond what man can see. Today, Carl Zeiss is a global leader in the optical and opto-electronic industries. With 11,249 current employees in the Group and offices in over 30 countries, Carl Zeiss is represented in more than 100 countries with production centers in Europe, North America, Central America and Asia. For more information on the breadth of solutions offered by Carl Zeiss MicroImaging, please visit www.zeiss.com/micro.

SOURCE: Carl Zeiss MicroImaging, Inc.