Presentation
Presentation: Comparison Of Results From Theoretical Sequence Search Engines And Peptide Mass Spectral Libraries For Selected Biological Samples
Source: Pittcon 2012
Summary
- Spectral library searching has many theoretical advantages over sequence searching
- Decoy libraries created from other species used with a simple target/decoy bias correction enable direct comparisons at FDR .01 with standard methods.
- Even at "low" coverage, library searching yielded equivalent or better results for real world samples.
- Library searching is an excellent addition to standard multiple search engine strategy.
- For known standards with high coverage, library searching is far more sensitive.
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