Product/Service
Light Induced Fluorescence (LIF) Sensor
•Natoli Tablet Compression Accessories Catalog
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As a valuable new analytical process technology, the LIF Sensor was designed for process cleaning validation, liquid applications and blend uniformity endpoint monitoring.
The advanced technology of the LIF Sensor has enabled real-time monitoring of fluorophore solutes via intrinsic fluorescent sensing in the solid state that has not been previously possible. The LIF Sensor provides remarkable sensitivity, a wide dynamic range, and low detection limits, resulting in improved product quality by reducing process upsets, lower annual product waste, improved root-cause analysis during manufacturing quality incidents often common within the pharmaceutical industry, improved process efficiency by reducing manufacturing processing time, and improved operator safety via an in-line approach.
Since fluorescence is approximately 1,000 times more sensitive than absorbance spectroscopy, the LIF Sensor can accurately measure residual Active Pharmaceutical Ingredients (APIs) in both rinse water and directly on surfaces. This field analysis capability provides near real-time cleaning validation and eliminates the need to swab and send samples to the lab for High Performance Liquid Chromatography (HPLC) analysis, which can take days, or even weeks.
Easily adaptable to different types of pharmaceutical blenders, the LIF Sensor's integral positional sensor can determine the X-Y axis rotation of a bin blender or the Y-Z rotation of a V-blender. The small, self-contained design and multifaceted mechanical and automation attributes provide for a robust sensor that is field deployable across a wide range of manufacturing scenarios.
Benefits
- Generates process knowledge leading to better process control
- Reduction in cycle time due to process understanding
- Improved operator safety by reducing operator exposure during sampling
- Adaptable to many pharmaceutical unit operations including blenders, mixers, reactors, and CIP skids
- Reduced cleaning cycles and rapid equipment turnaround times
- Can be cart mounted for portability for cleaning assurance testing
•Natoli Tablet Compression Accessories Catalog
•Natoli Replacement Parts Catalog
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