Article
Management Of Fluid Transfer In Single-Use Systems
June 1, 2011
•Article: Management Of Fluid Transfer In Single-Use Systems
By Pall Life Sciences - BioPharmaceuticals
When designing a single-use process containing many unit operations, the initial focus of attention is often the compounding and purification steps involving process equipment such as bioreactors, mixers, tangential flow filters for concentration/diafilitration, and direct flow filters for particle or bioburden reduction or sterilization. Although these are critical operations in many biomanufacturing processes, there are also many other important considerations such as storage of liquids and solids, protection of the product and immediate environment, transfer of raw materials and components, skills and protection of operators, fluid transfer, and safe handling of waste.
Advances in equipment have facilitated many of these operations. For example, the use of isolators is now standard practice in many facilities, replacing in some cases large cleanrooms, and elimination of procedures heavily dependent on operator skills. Similarly, systems for rapid and safe transfer of solids, components and waste were developed almost fifty years ago, and have transformed the working environments and safety of many processes. Single-use components and systems are often an integral part of these developments, and close working relationships between equipment manufacturers have resulted in enhanced technologies, with benefits recognized and welcomed by regulatory authorities.
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