Application Note
Optimizing Topical Skin Care Formulations And Production
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•Application Note: Optimizing Topical Skin Care Formulations And Production
Particle size and zeta potential are fundamental parameters that control stability of suspensions. The present study was conducted to optimize manufacturing process variables (chemical composition, temperature, degree of homogenization, cooling rate, etc) by studying variations that occur in either, or both, the particle size (PS) and zeta potential (ZP) of a commercially available raw material used in skin care product formulation and manufacture.
The raw material in question is an encapsulated retinol system and it is, like many typical cosmetic creams and lotions, a highly complex multicomponent formulation. By characterizing the functionality of this dispersed suspension it is possible to gain an understanding of the critical factors that control the process, providing quality assurance for the final product and identifying the surface chemistry that provides the optimal level of product functionality for the final product.
Skin is a unique, continuous external covering that protects us from toxic environmental elements and disease. The skin is also part of the natural resistance of the body; it protects us against invasion by microorganisms. Yet despite its well-known barrier properties, skin itself must be protected.
The aging process of the skin can be divided into two categories; (1) intrinsic aging or chronological changes and (2) extrinsic aging or photo aging, resulting from continuous exposure to ultra-violet radiation and other environmental factors. Both aging processes occur simultaneously, thus complicating any study of skin. It is known, however, that photo aging results in noticeable differences to the skin's character such as, wrinkles, roughness, sallowness, mottled dyspigmentation, and a variety of benign and malignant neoplasms [1]. Skin is in constant danger of oxidative injury because it is continuously exposed to irradiation by visible and ultra violet light. It is well known that membrane damage occurs in the skin lipids because of exposure to UV rays.
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•Application Note: Optimizing Topical Skin Care Formulations And Production
