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Powder Characterization Techniques For Wet Granulation Applications
Source: Freeman Technology Ltd
Click Here To Download:•Guest Column: Powder Characterization Techniques For Wet Granulation Applications
By Tim Freeman, Freeman Technology
Wet granulation is a routine unit operation within the pharmaceutical industry, and a common precursor to tableting. It is typically carried out as a batch process, with endpoint detection an important issue. Here, dynamic powder rheometry offers proven benefit. By providing sensitive detection of the transition from wet mass to granulate, using a property that is independent of scale, this powerful analytical technique accelerates scale-up and over the longer term improves manufacture.
High shear mixers tend to be the preferred choice for wet granulation. After initial blending of the dry constituents, a solution is added to wet the blend and promote granulation to a desirable endpoint. Control is achieved by manipulating the amount of granulation solution added, the rate of addition, processing time and the impeller speed.
Two major issues complicate process development. Firstly, wet granulation is often an intermediate step so determining an optimal endpoint frequently involves working-up a number of batches, through to a final end product. This can be a lengthy process but is essential if the in-process performance of material exiting the granulator cannot be correlated with easily measurable granulate properties. Click Here To Download:
•Guest Column: Powder Characterization Techniques For Wet Granulation Applications
