Application Note
Tighter Conductivity Control In Chromatography And Purification Systems (Flow Through Sensor)
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•Application Note: Tighter Conductivity Control In Chromatography And Purification Systems (Flow Through Sensor)
By Emerson Process Management, Rosemount Analytical Liquid Division
Biopharmaceutical Chromatography Systems are designed for separating and purifying proteins and bio-engineered products. Flow systems are compact in design to maximize throughput. No dead legs in process pipe can exist since unswept areas are more challenging to completely clean as well as delaying product throughput. The systems must maintain a hygienic design. Wetted surface finish must be < 20 µinch Ra and material traceability is important to maintain system integrity.
Conductivity measurement plays an important role in the purification process. Conductivity is one of the determinants of when to start and when to end the collection process. Tighter conductivity controls will increase purity yields. In addition, it may improve secondary collection processing.
Conductivity is a critical determining factor to determine cleanliness. Often, sensors that require tees or larger branches to be properly installed will create half filled process pipes, which lead to lower conductivity values. The conductivity sensors need to differentiate between CIP cleaning fluids and rinse water.
The PUR-sense Model 245 Flow Through Conductivity Sensor from Rosemount Analytical can accurately monitor the protein purification process. Improved accuracy can be achieved using FOUNDATION® Fieldbus Function Block Logic. The conductivity sensors can be optimized at the collection points and automatically switched at a predetermined conductivity value, therefore maximizing product yields.
Click Here To Download:•Application Note: Tighter Conductivity Control In Chromatography And Purification Systems (Flow Through Sensor)
