A Model For Roller Compaction Formulations Based On Tabletability Performance
The purpose of these studies are to evaluate the effect of lactose monohydrate, aspirin content, naproxen, and ibuprofen of the tabletability performance of roller compacted Avicel PH200 and Prosolv HD90 blends as a preliminary screening study towards development of a model for roller compaction formulations.
The excipient blends containing either Avicel PH200 or Prosolv HD90 in combination with different proportions of spray dried lactose monohydrate, aspirin, naproxen and ibuprofen were roller compacted, milled and compressed on a single station carver press. Tablets were made at compression forces ranging from .2 to 2.6 metric tons. Physical properties such as blend bulk and tap densities; tablet thickness and breaking forces were measured. Carr’s indices and tensile strengths were calculated.
The results of the flowability were based on Carr’s Index measurement to find any differences between the physical properties measured for the Avicel PH200 blends compared to Prosolv HD90 blends for the best tabletability performance.