Controlled-Release Tablets

Whatever challenges these complex technologies present for your project, chances are we have already overcome them in a previous project. Patheon offers the full arc of services and resources to take you seamlessly from early development to market quickly and efficiently.

The scientists at Patheon have years of experience in the development and manufacture of controlled-release tablets for a wide variety of molecules.

With Patheon you'll have access to many dose form technologies, royalty-free, so you can give your molecule exactly what it needs while creating a product precisely suited for your target market.

• Coated and Uncoated Tablet: Offers a broad range of shapes, sizes, finishes (printing, embossing, score-marks) and release profiles.
• Microtablet: Low dose tablets – delivered by device, capsule or sachet – that enable you to offer variable dose strengths without changing your formulation or process.
• Tabletted Multiparticulates and Coated Beads: Gives you the versatility of these dose forms pressed into a simple tablet.
  • Coated Beads are a simple solution for complex challenges
    • Less susceptible to dose dumping with predictable gastric emptying
    • Less effected by food compared to monolithic dosage forms
    • Minimum inter- and intra-subject variability
    • Reduced risk of local irritation to GI tract
    • Multiple releases of multiple ingredients throughout GI tract in a single dose
    • Adjust dose strength, or offer a range of dose strengths, without changing the formulation or process
• Tablet Inlayed Within a Tablet: A combined dose with multiple release options.
• Multilayer Tablet: Pairs a controlled-release layer with an immediate-release layer or with another API or excipient in a single tablet.
  • Bilayer Tablet - combination of two APIs, or an immediate-release layer and controlled-release layer, in a single tablet.
  • Trilayer Tablet - combination of two APIs, or an immediate-release layer and controlled-release layer, separated by a middle placebo layer in a single tablet.
  • Multilayer Advantages:
    • Improved Patient Compliance Simplifies management for chronic diseases by combining complimentary medications and reducing the total number of pills a patient needs to take.
    • Better Efficacy Synergistic combinations and mechanisms to improve ADME and drug resistance.
    • Simplified and Cost-Effective Handling and Distribution Especially for HIV medications.

Effective Life Cycle Management Strategy New products from proven molecules, patent and market exclusivity, may also extend patent exclusivity.