The modules utilize proprietary active and passive heat transfer surfaces to solidify aqueous solutions through a controlled process that provides dendritic ice formation. This process is identical to the processes that occur in Integrated Biosystems' CryoCans and CryoVessels. Because proteins are quickly frozen between growing dendrites, they are protected from degradation mechanisms (aggregation, precipitation, and denaturation) commonly observed when freezing takes place either too quickly or too slowly.
Integrated Biosystems offers a full range of scalable Cryotrol systems for process development, pilot, and commercial scale production. When controlled by the CryoTrol freeze/thaw system, the CryoWedge precisely duplicates the phenomenological events in large CryoVessels.
Integrated Biosystems, Inc., 536 Stone Rd., Suite H, Benicia, California 94510. Tel: 707-748-1900. Fax: 707-747-6450.