Custom Powder Systems Announces Dramatic Yield Increase Through Use Of Anti-Segregation TechnologiesSource: Custom Powder Systems
A unique solution improves yields from less than 75% to over 98%.
"Our material handling process was very inefficient and we were lucky to yield 50% in-spec product” says the Director of a major generic pharmaceutical company, "and the handling labor was extensive. I can't even begin to tell you how frustrating it was."
The Director is discussing the problem his company had with manufacturing one of its key products.
"Saying this formulation was a challenge is an understatement. The majority of the ingredients are fines blended with large spherical granules. Any movement or disturbance causes the spheres to float to the top of the batch. We knew that the main cause of the low yields was due to ingredient segregation occurring between the V-blender and the Tablet Press but we were at a loss to find a feasible cure to the segregation issue.”
The yield issues came to the attention of Custom Powder Systems (CPS) during an on-site visit for another on-going project. As the CPS team walked through the process it was found that the product was loaded into drums from the V-blender. The drums were then moved across the facility into the compression room and hand scooped from drums into the Tablet Press feed inlets.