Develop A Functional And Active Film Coating In A Conventional Pan Coater

Pharmaceutical coating is generally performed using either an aqueous or solvent process in a rotary pan or fluidized bed, which utilizes a large amount of energy and expensive HAVC systems. Solvent coating also introduces explosivity risks and pollutes the environment. Therefore a dry powder coating process has been investigated with the following objective:

• Acceptable functional and cosmetic coating
• Less energy consumption
• Environmentally friendly
• Low capital and maintenance cost
• Robust GMP coating process
• Acceptable by regulatory bodies, common excipient

Early studies demonstrated electrostatic dry powder coating could produce coated tablets and pellets with acceptable appearance. In this study, ibuprofen tablets were used as a model to evaluate the coating process, the coating performance before and after storage under accelerated stability condition, and the coat uniformity.