A Drug Delivery Approach To Achieve Zero-order Release Kinetics
There are several techniques available for formulation scientists to achieve the zero order release kinetics. However, most of the techniques are quite complex, expensive, time consuming, and difficult to manufacture. There are many formulations developed so far and are available in the literature, but there are very few formulation techniques that have resulted in a successful zero order release.
Hence, we wanted to develop a simple formulation based on a matrix based system with a membrane coating to achieve zero order release for freely water soluble Active Pharmaceutical Ingredients (API). A simple technique of obtaining zero-order release from hydrophilic matrix based tablets with membrane coating was developed to release up to 12 hours. In this technique, methacrylic acid copolymers and cellulose polymers along with other insoluble ingredients were used in appropriate ratios, compressed into tablets and coated. A freely soluble API was selected as a model drug. Different ratios between the drug and total polymers were evaluated so that the drug release rate remains constant. Extent of zero-order drug release from tablets was confirmed by fitting the dissolution data to the suitable mathematical equations.