Eliminating Inspection Labor Costs On Your Blister Packaging LinesSource: Bonfiglioli Engineering SPA
By Giuseppe Bonfiglioli
Production of tablets and capsules is carried out in cleanrooms and under stringent procedures as per GMP requirements. However the process also relies on machines and machine operators whereby misappropriate handling can result in a faulty blister pack containing micro leaks in the packaging thus allowing air and moisture to enter the blister and damage the product. What the Q&A department usually does to make sure blister packs are not leaking. This method is to perform a Methylene Blue Dye Test, which consists of placing a sample blister pack in the methylene blue dye for approx. 1 min after which a vacuum is applied to the container. As soon as the vacuum is released, should there be any hole in the blister pack the dye will replace the air that was sucked out under vacuum. The dye enters the blister and usually the tablet inside is stained with color.