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FMS-760 Headspace Oxygen Analyzer

Source: Lighthouse Instruments

FMS-760 Headspace Oxygen Analyzer
The FMS-760 Headspace Oxygen Analyzer is a non-destructive oxygen gas analyzer for monitoring headspace oxygen concentration in sealed parenteral containers. This compact benchtop oxygen analyzer utilizes a patented laser absorption technique developed with funding from the Food and Drug Administration. Light from a near-infrared laser is tuned to match an internal absorption frequency of the oxygen molecule and passed through a container in the headspace above the product.
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Datasheet: FMS-760 Headspace Oxygen Analyzer

The FMS-760 Headspace Oxygen Analyzer is a non-destructive oxygen gas analyzer for monitoring headspace oxygen concentration in sealed parenteral containers. This compact benchtop analyzer utilizes a patented laser absorption technique developed with funding from the Food and Drug Administration. Light from a near-infrared laser is tuned to match an internal absorption frequency of the oxygen molecule and passed through a container in the headspace above the product. The amount of laser light absorbed is proportional to the oxygen concentration in the headspace. This non-destructive measurement method allows for the rapid analysis of 100% of product.

Benchtop systems are used for at-line process monitoring and laboratory applications. Systems can be mounted on carts and wheeled from line to line for in-process monitoring and troubleshooting activities or be permanently situated in laboratories for product development, release testing, and QC investigations.

FMS-760 Headspace Oxygen Analyzer Applications:

  • Leak detection
  • Container closure integrity studies
  • IPC monitoring of oxygen levels during the filling of oxygen-sensitive product
  • Optimization and validation of purging systems on filling lines
  • Oxygen degradation studies
  • Stability trends, end-of-shelf life studies

Seven 10 mL clear glass vials were prepared with known oxygen concentrations of 0, 1, 2, 4, 8, 13, and 20.1% with a balance of nitrogen. The oxygen concentration in each vial was measured ten times using the FMS-760 Headspace Oxygen Analyzer. The FMS-760 measures the absorption of laser light by oxygen molecules in the container headspace. The amplitude of the absorption signal is proportional to the oxygen concentration.

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Datasheet: FMS-760 Headspace Oxygen Analyzer

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