Transforming Liquid SMEDDS Into Solid SMEDDS TabletsSource: Grace
Self-emulsifying drug delivery systems (SEDDS) have become effective tools to help increase oral bioavailability of poorly soluble drugs. One of the challenges of these liquid, lipid-based systems is the difficult and costly process of filling highly viscous lipids into capsules. In addition, the low molecular weight polar molecules present in lipid formulations may penetrate and plasticize gelatin capsule shells, restricting the concentration of propylene glycol and related co-solvents that can be used, resulting in reduced efficacy of the formulation.
Syloid® XDP silica has been specifically engineered to overcome these challenges of formulating lipid based systems into tablets and capsules. The effectiveness of Syloid® XDP silica in this application is demonstrated by converting a sample liquid SMEDDS system into a tablet formulation.