Freezing Point Depression Measurement Using A Built Temperature Logging Device
Temperature is a critical parameter monitored in Freeze-Drying production and manufacturing processes to ensure reproducible product quality, process efficiency and productivity. Research is carried out into the development of methods and control systems that can acquire accurate low temperature measurements for commercial use.
In freeze-drying applications this research could be used to determine solute concentrations within vials, the time at which complete solidification is obtained during the freezing stage of the process and information on crystal morphology.
The objective of this project is to monitor very low freezing points because of a direct relationship to osmolality of a system. A high speed data acquisition system (DAQ) for remote low temperature recording has been illustrated for its ability to acquire freezing point values in the range 0oC to -21oC suitable for deployment within a freeze-dryer. The feasibility of calibrating the system against freezing point profiles is also discussed.