In Silico and In Vitro Tools for the Rational Design of Novel Subunit Vaccines

Source: Lonza Ltd.

Date: 10/29/2014
Time: 12:00 PM - 1:00 PM (Eastern) 

Dr Noel Smith, Senior Group Leader, Applied Protein Services, Lonza Biologics, Cambridge, UK.

Subunit vaccines have been shown to have an excellent safety and stability profile compared to the more traditional inactivated or live attenuated vaccines. However this increased safety is often accompanied by the fact that subunit vaccines are often less immunogenic and require adjuvants to induce immunological memory. Rational design approaches can be used to identify the immunogenic parts of the pathogen that contain the B cell and T cell epitopes required for an immune response. Rationally designed vaccines are ultimately composed of antigens and adjuvants that elicit strong immune responses against specific epitopes to protect against a specific pathogen.