Ion Exchange Resins Used For A Controlled Release Orally Disintegrating Tablet (ODT)
Ion exchange resins (IER) are cross-linked, water insoluble, polymer-carrying, ionizable functional groups. Synthetic ion exchange resins are usually cast as porous beads with considerable external and internal pore surfaces for loading. The resins are prepared as spherical beads 0.5 to 1.0 mm in diameter. These appear solid even under the microscope, but on a molecular scale the structure is quite open. Drugs can be loaded onto the resins by an exchange reaction, forming a drug-resin complex (drug resinate). Ion exchange can be defined as a reversible process in which ions of like sign are exchanged between liquid and solid, a highly insoluble body. The drug is released from the resinates by exchanging with ions in the gastrointestinal fluid, followed by drug diffusion. As high molecular weight water insoluble polymers, the resins are not absorbed by the body and are therefore inert. Ion exchange resins are used for variety of applications in pharmaceutical industry.
- Taste Masking
- Disintegrant / Superdisintegrant
- Solubility Improvement
- Drug Stabilization
- Improved Flowability
- Modified/Sustained Release Profiles