LF-Laser Laboratory Oxygen Headspace Analyser For Lyophilised VialsSource: Bonfiglioli Engineering SPA
A revolutionary method has now been developed for detecting oxygen in the headspace of sealed vials using Laser Absorption Spectroscopy.
A revolutionary method has now been developed for detecting oxygen in the headspace of sealed vials using Laser Absorption Spectroscopy. Laser absorption spectroscopy is an optical measurement method for rapid and non-destructive gas analysis.
Light from a near-infrared semiconductor laser is tuned to match the internal vibrating frequency of the oxygen molecule. The rays are passed through the headspace region of a container. Energy from the laser is absorbed by the target molecules and thus begin to vibrate. The light is then scanned in frequency and detected by a photo detector. Using Spectroscopy the absorption curve is analysed whereby information about the headspace oxygen concentration is calculated. If no energy was absorbed then it would mean that the target molecule was not present.
The LF-Laser is a semi-automatic Oxygen headspace analyser. The vial is inserted in a test chamber and a vacuum decay test is performed on the vial. If a leak is detected then it will be rejected. If no leak is present then the test will proceed to the Oxygen headspace analysis whereby the laser will be passed through the headspace. At this point the vial is surrounded by a vacuum inside the test chamber therefore there will be no ambient oxygen to interfere within the laser path. This will mean that the laser will only act on the internal oxygen present and no outside purging is required to deplete the oxygen surrounding the vial. The colour or glass type of the vial under test does not influence the result. An indication of the actual oxygen level detemined is displayed. The LF Laser machine is fully computerised utilising a SCADA platform. The software is easy to operate and includes utilities such as a products database, Statistical reports etc. A printer may also be installed for printing test results and parameters. The machine includes an Auto Self Test system using calibrated Check Vials where by the machine is self challenged as frequently as desired to assure 100% reliability. All necessary validation documents are available.