Newsletter | March 21, 2013

03.21.13 -- Manufacturing vs. R&D: The Problem Is Powder Flowability

Pharmaceutical Online Newsletter
Departments:
Solid Dose Liquid Dose Packaging QA/QC
Inspection Critical Environments Supply Chain  
Featured Focus: Solid Dose
Manufacturing vs. R&D: The Problem Is Powder Flowability
By Bob G. McGregor, General Manager, Brookfield Engineering
Tablet production depends on the steady flow of powder from a feed hopper to the tablet machine. Hang-ups are unwelcome because they interrupt production, and manufacturing must execute a rigorous restart procedure. The blame, whether deserved or not, falls on R&D, because they have responsibility for evaluating formulations for proper scale up and smooth processability.
ARTICLE: Considerations When Selecting A Pharmaceutical Feeder To Reduce Manufacturing Costs
By Chad Lorensen, Schenck AccuRate
Metering dry powders in the pharmaceutical industry is not a new idea. Several common applications have been using gravimetric and volumetric dry material feeders for many years.
WHITE PAPER: Developing A Solid Maintenance Plan With An Industrial Vacuum
By Paul Miller, Nilfisk Industrial Vacuums
In developing a comprehensive and effective cleaning program, pharmaceutical plants should understand the importance of choosing the correct vacuum for their application. This machinery represents a critical component in helping to minimize or avoid certain risks.
WHITE PAPER: The Importance Of Mixer Testing And Selection
By Christine Banaszek, Application Engineer
If you haven’t tested a variety of mixers during the past few years, forget all the rules you had relied on to distinguish one mixer from another.
BROCHURE: Pharmaceutical Roller Compactor: WP 200
PRODUCT: Used Roller Compactors
» Liquid Dose
WHITE PAPER: Container Closure Integrity Testing Method Development And Validation For Prefilled Syringes
By Lei Li, PTI Packaging and Inspection Systems
Utilization of prefilled syringes as a preferred container closure system for biologics has been increasing. As a primary container closure system, prefilled syringes must provide an integral barrier that protects drug product stability and sterility throughout its entire shelf life.
PDF: Ultra Cool Recirculating Chiller
DOWNLOAD: Too Much, Too Soon? Phase-Appropriate Is Better
PRODUCT: Peristaltic Pump For Liquid Pharmaceuticals
PRODUCT: Custom Liquid Filling Equipment
» Packaging
WHITE PAPER: Aseptic Blow/Fill/Seal: A Sustainable Process For Packaging Pharmaceutical Liquids
By Chuck Reed, Weiler Engineering, Inc.
Aseptic blow/fill/seal systems for packaging pharmaceutical liquids incorporate materials and processes that provide critical advantages for sustainable initiatives.
PRODUCT: Accu-Seal 8000 Series Validatable Vacuum Sealers
PRODUCT: X-Ray Inspection: E-Z Tec XR-Clean
» QA/QC
ARTICLE: The Impact Of Dissolution On Particle Size And Particle Shape Of Multicomponent Drug Delivery Systems
By Adam Keith and Peter Bouza, Micromeritics Pharmaceutical Services
The particle size and particle shape of multicomponent controlled-release drugs must be considered during their dissolution. Though the size and shape of the particles are well known during formulation and manufacture, oftentimes, little is known about the changes in size, shape, and morphology during dissolution.
WHITE PAPER: Improve The Success Of Shop Floor Implementations
WHITE PAPER: Selecting A HART Handheld
APPLICATION NOTE: Hygienic Processing: Elimination Of Dead-Space Volume
MANUAL: A Guide To Corrosion-Resistant Piping And Tubing In Pharma/Biopharma
PRODUCT: QCanywhere Cloud-Based Quality Control
» Inspection
PRODUCT: Fully Automatic Cap Welding Machine Type SM 965
PRODUCT: Micro Leak Testing Of Filled/Sealed Bottles, Cups, Rigid Containers
PRODUCT: Metal Detectors
PRODUCT: Pharmaceutical Track And Trace Checkweigher
» Critical Environments
WHITE PAPER: Water Type And Cleaning For NuAire Incubators
BROCHURE: Integrated Containment Systems
DATASHEET: Pharmaceutical Flexible Isolator: FlexiVac
DOWNLOAD: Walker Barrier Custom Isolators And Containment Systems
PRODUCT: Glove Boxes
» Supply Chain
ARTICLE: TAP For CRT: Challenges Due To Product Temperature Criteria
By Ken Maltas and Iftekar Ahmed, ThermoSafe, Sonoco Protective Solutions
There has been significant discussion over the past few years around TAP (temperature assured packaging) for CRT (controlled room temperature). Manufacturers and regulators have not yet decided how they want to handle this type of product, although some countries, such as Saudi Arabia, have already mandated that CRT products be shipped in proper TAP.
ARTICLE: Recent Findings On The Potential For Temperature Damage During Shipping And Handling In The US: RX 360 Part II
By Nick Puro, President, Temptime Corporation
This article focuses on the recent research done on the impact of temperature damage, or perceived temperature damage, during shipping and handling in the United States.
ARTICLE: Active Cold Chain Services: With You Every Step Of The Way
CASE STUDY: How DSC Helped Kimberly-Clark Healthcare Drive Down Costs While Improving Service
CASE STUDY: Everest Biotech Distribution Challenge
BROCHURE: GxP Compliance In The World Courier Network
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