By Bob G. McGregor, General Manager, Brookfield Engineering
Tablet production depends on the steady flow of powder from a feed hopper to the tablet machine. Hang-ups are unwelcome because they interrupt production, and manufacturing must execute a rigorous restart procedure. The blame, whether deserved or not, falls on R&D, because they have responsibility for evaluating formulations for proper scale up and smooth processability.
By Chad Lorensen, Schenck AccuRate
Metering dry powders in the pharmaceutical industry is not a new idea. Several common applications have been using gravimetric and volumetric dry material feeders for many years.
By Paul Miller, Nilfisk Industrial Vacuums
In developing a comprehensive and effective cleaning program, pharmaceutical plants should understand the importance of choosing the correct vacuum for their application. This machinery represents a critical component in helping to minimize or avoid certain risks.
By Lei Li, PTI Packaging and Inspection Systems
Utilization of prefilled syringes as a preferred container closure system for biologics has been increasing. As a primary container closure system, prefilled syringes must provide an integral barrier that protects drug product stability and sterility throughout its entire shelf life.
By Chuck Reed, Weiler Engineering, Inc.
Aseptic blow/fill/seal systems for packaging pharmaceutical liquids incorporate materials and processes that provide critical advantages for sustainable initiatives.
By Adam Keith and Peter Bouza, Micromeritics Pharmaceutical Services
The particle size and particle shape of multicomponent controlled-release drugs must be considered during their dissolution. Though the size and shape of the particles are well known during formulation and manufacture, oftentimes, little is known about the changes in size, shape, and morphology during dissolution.
By Ken Maltas and Iftekar Ahmed, ThermoSafe, Sonoco Protective Solutions
There has been significant discussion over the past few years around TAP (temperature assured packaging) for CRT (controlled room temperature). Manufacturers and regulators have not yet decided how they want to handle this type of product, although some countries, such as Saudi Arabia, have already mandated that CRT products be shipped in proper TAP.
By Nick Puro, President, Temptime Corporation
This article focuses on the recent research done on the impact of temperature damage, or perceived temperature damage, during shipping and handling in the United States.