By Trisha Gladd, Editor, Pharmaceutical Online and Bioresearch Online
In an industry as conservative as the pharmaceutical industry, it is common practice to be adverse to new technologies because they are often viewed as too much of a risk. However, in this effort to play it safe, companies force themselves into a repetitive state of employing technologies that may not be the most efficient or effective. Rather than getting stuck in old habits — or conversely, jumping too quickly into new ones — Merck has put together a group of teams it calls the Technology Encouragement Collaborators, or TEC, to look at new technologies and determine whether or not to implement them.
By Adrian Possumato, Vice President, Healthcare Packaging, Multisorb Technologies
Maintaining drug stability, quality, shelf life, safety, and efficacy is often achieved by using a sorbent to manage moisture, remove oxygen, or eliminate volatiles in the drug or device packaging headspace. With so much at stake, sorbent insertion is a critical step in the pharmaceutical packaging process. Unfortunately for manufacturers, automated insertion can create challenges on the packaging line when not properly implemented by a reputable supplier that can offer technical expertise and customized solutions.
By Georges Schmidt, Hach Lange Sàrl, Geneva, Switzerland
In the past three decades, ozone has become a very important and efficient tool to achieve high-quality pharmaceutical-grade water. This paper will address two main topics that are critical for the effective use of ozone within the water processes of the life sciences industry.
By Uwe Amann, Harro Höfliger Packaging Systems
The majority of pharmaceutical products have to enter the blood stream in order to be effective. They can be taken orally, via the intestine, by injection, or infusion.
By Annette Kaya, Andrea Uebele, Anke Seeger, et al., M+W Process Industries
Contract manufacturer DSM Biologics, at its current good manufacturing practices (cGMP) facility in Groningen, The Netherlands, provides services for clinical development and commercial production based on mammalian cell culture technology.
By Andrew W. Goll, Technical Sales Manager, Weiler Engineering, Inc.
The aseptic blow-fill-seal (B/F/S) process has proven to be an ideal system for the creation of a wide variety of container shapes and sizes used for packaging sterile pharmaceutical liquids.
By G. McDonnell, STERIS Corporation
Various sterilization methods (including gamma irradiation and ethylene oxide) have been widely used for terminal medical device sterilization. No single method offers the perfect sterilization solution for every application.
By Michael Boetzkes, Quality Manager, Vaisala Canada Inc. Life Science Division
Using the instrument maker's tolerance, there is often a higher risk of an “out of tolerance” message appearing on a calibration certificate; this costs money. Consider the following scenario: You have just received back from calibration the set of temperature sensors used to monitor the warehouse. Most of the instruments have been shown to be within manufacturer published tolerances. A few of the instruments, though, are listed as out of tolerance. Now the fun starts!
By Robert Rosen, Filamatic
Solve foaming problems with our bottom-up filling technique. This technique can be used on both semi-automatic and automatic equipment. Bottom-up filling allows the nozzles of each pump to be inserted into the container and to rise just above the liquid as the liquid rises. Bottom-up filling ensures a smooth fill and eliminates the foaming of your product.