Optimizing The Sterile Filtration Of Cellulose Based Ophthalmic SolutionsSource: Parker domnick hunter Process Filtration
Manufacturers of ophthalmic products are constantly looking to develop innovative new multipurpose solutions for contact lens users and prescriptive drugs for treatment of eye conditions. One of their main aims is to increase the residence time of ophthalmic solutions in the eye, adding to user comfort when using contact lens products and increasing the efficacy of delivery of the active pharmaceutical ingredient (API) in prescription drugs. This has driven the use of viscosity enhancers such as cellulose based additives and, more recently, hyaluronic acid.
Common cellulose based additives used in existing ophthalmic products on the market today include carboxymethylcellulose (CMC), hydroxylethylcellulose (HEC) and hydroxypropylmethylcellulose (HPMC). These viscosity enhancing ingredients can pose challenges for sterile filtration.
Parker domnick hunter recently had the opportunity to work with a large global ophthalmic manufacturer on the optimization of the production line for a particularly difficult to filter solution for the treatment of dry eye, which contains CMC.
During the optimization process it became evident that the filtration train was just one of the factors influencing the volume throughputs which could be achieved. There are a number of processing parameters which may also contribute and it is hoped that by highlighting these issues, other manufacturers will be able to take them into account when implementing their own process improvement initiatives.