Part I: Excipient Blends Poster
To evaluate the effect of lactose monohydrate on the tabletability performance of roller compacted Avicel PH200™ and prosolv HD90™ blends as a preliminary screening study towards development of a model for roller compaction formulation.
Excipient blends containing either Avicel PH200™ or Prosolv HD90™ in combination with different proportions of spray dried lactose monohydrate were roller compacted, milled, and compressed on a single station carver press. Tablets were made at compression forces ranging from 0.2 to 2.6 metric tons. Physical properties such as blend bulk and tap densities; tablet thickness and breaking force were measured. Carr’s indices and tensile strengths were calculated. Effect of addition of lactose monohydrate on the compressibility, compactibility and tabletability of the formulations was investigated.
The flowability based on Carr’s Index measurement decreased slightly with addition of lactose monohydrate for both Avicel PH200™ and Prosolv HD90™ blends. In general, Avicel PH200™ blends flowed better as compared to Prosolv HD90™ blends. Addition of lactose monohydrate did not have an impact on the compressibility profiles of Avicel PH200™ blends, whereas a slight reduction in compressibility was observed in the case of Prosolv HD90™ blends. With Avicel PH200™ blends, there was an increase in compatibility and tabletability with addition of lactose at the 25% level, but further increase to 50% lactose resulted in a drop in compactibility and tabletability. Prosolv HD90™ performed better on compactibility and tabletability as compared to Avicel PH200™, but exhibited a decrease in performance with a gradual increase in the proportion of lactose.