Part II: Aspirin Blends Poster
To evaluate the effect of increasing aspirin content on the tabletability performance of roller compacted Avicel PH200™ and Prosolv HD90™ blends as a part of a larger study towards development of a model for roller compaction formulations.
Aspirin was blended with either Avicel PH200™ or Prosolv HD90™ in different proportions and blends were roller compacted and milled. Pre-roller compacted blends, post-roller compacted, and milled granules were compressed on a single station carver press. Tablets were made at compression forces ranging from 0.2 to 2.6 metric tons. Physical properties such as blend bulk and tap densities, tablet thickness and breaking force were measured. Carr’s indices and tensile strengths were calculated. The effect of increasing the aspirin content on the compressibility, compactibility and tabletability of the formulations was investigated.
Based on Carr’s index measurement, the flowability decreased slightly after roller compaction. Minor differences in compressibility were observed between pre and post roller compacted material. Compressibility decreased slightly with aspirin content at low compression forces for both Avicel PH200™ and Prosolv HD90™ blends. At higher compression forces, the trend was reversed. Compactibility and tabletability showed a reduction on roller compaction and with increasing aspirin content for all the blends. In the post-roller compacted and milled granules, the Prosolv HD90™ blends had higher compactibility and tabletability as compared to the Avicel PH200™ blends.