Part III: Naproxen Blends Poster
To evaluate the effect of increasing naproxen content on the tabletability performance of roller compacted Avicel PH200™ and Prosolv HD90™ blends, as a part of a larger study towards development of a model for a roller compaction formulations.
Naproxen was blended with either Avicel PH200™ or Prosolv HD90™ in different proportions and blends were roller compacted milled. pre-roller compacted blends, post-roller compacted, and milled granules were compressed on a single station carver press. Tablets were made at compression forces ranging from 0.2 to 2.6 metric tons. Physical properties such as blend bulk and tap densities, tablet thickness and breaking force were measured. Carr’s indices and tensile strengths were calculated. The effect of the increasing naproxen content on the compressibility, compactibility and tabletability of the formulations was investigated.
The flowability decreased with an increase in naproxen content, but increased after roller compaction and milling in the case of both Avicel PH200™ and Prosolv HD90™ blends. Compressibility showed a decrease with an increase in naproxen content for all the blends. This trend was observed in both pre and post roller compacted material. Compactibility tabletability reduced with the addition of naproxen for all the blends. There was drop in compactibility and tabletability of the blends upon roller compaction.