Part IV: Ibuprofen Blends Poster

To evaluate the effect of increasing ibuprofen content on the  tabletability performance of roller compacted Avicel PH200™ and  Prosolv HD9O™ blends as a  part of a  larger study towards development of a model for roller compaction formulations.

Ibuprofen was blended with  either Avicel PH200™ or  Prosolv HD9O™ in  different proportions  and  the blends were roller compacted and  milled. Pre-roller compacted blends and post-roller compacted and milled granules were compressed on a single station carver press. Tablets were made at compression forces ranging from 0.2 to 2.6 metrictons. Physical properties such as blend bulk and tap densities, tablet thickness and breaking force were measured. indices and tensile strengths were calculated. The effect of increasing the ibuprofen content on the compressibility, compactibility and tabietability of the formulations was investigated.

In the case of Avicel PH200™ ibuprofen blends, Carr’s indices increased on addition of ibuprofen in the  pre-roller compacted blends, indicating a reduction in flowability. This effect wa.s not observed in the  post-roller compacted granules. For Prosolv HD9O™ ibuprofen blends, no major change in flowability was observed before or  after  roller compaction. Compressibility of the formulations decreased with an increase in ibuprofen content across all blends prior to and after roller compaction. Cornpactibilities did not show a major change on addition of ibuprofen in the  pre-roiler  compacted. blend., but  increased  slightly  with  ibuprofen  content  in the  post-roller compacted granules. Tabletability reduced with increasing ibuprofen content for all blends. In the post-roller compacted material, the increase in  tabletability on addition of ibuprofen was  less prominent as compared  to pre-roller  compacted blends.