Product/Service

Pharmaceutical Microbial Detection Systems

Source: Azbil BioVigilant, Inc.

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AzbilBioVigilant’s IMD-A systems detect the presence of microbes by simultaneously measuring the size and intrinsic fluorescence of every particle in an aerosol sample as it is drawn through the instrument and interrogated by a laser.

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AzbilBioVigilant’s IMD-A systems detect the presence of microbes by simultaneously measuring the size and intrinsic fluorescence of every particle in an aerosol sample as it is drawn through the instrument and interrogated by a laser. Microbes possess certain organic auto-fluorescent compounds necessary for cellular function, including NADH, riboflavin, and DPA (in the case of endospores). When these intrinsic fluorophores are excited by laser, they auto-fluoresce and this signal is measured. The IMD-A uses this fluorescence measurement as a critical metric within its proprietary and deterministic algorithms to differentiate a particle of biological origin (e.g. a bacterium) from an inert (e.g. dust) particle.

IMD-A systems are ideally suited wherever timely information about a critical environment is important. IMD-A systems set a standard for speed in rapid microbial detection, delivering continuous real-time data about one’s environment empowering the user to detect, react to, and prevent contamination with a sensitivity not previously achievable with traditional methods. The most common IMD-A applications involve the monitoring of critical environments (i.e. cleanrooms) in the Pharmaceutical manufacturing and other Life-Science industries. Aseptic fill lines, sterility test suites/isolators, and RABS areas are all key locations. Other specialized applications include personnel training, compressed gas testing, process simulations (e.g. water and media fills), root-cause investigations (e.g. sourcing of building mold contamination), engineering validation (e.g. determining optimum HVAC settings) and risk assessment/process improvement (the synchronized IMD-A webcam works great for this application). AzbilBioVigilant’s team of Field Application Scientists is dedicated to helping customers achieve implementation success in these general and more specialized applications. Please contact us to explore your requirements.
 

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