News | November 27, 2012

Quadro Ytron® ZC Disperser Reduces Batch Times In Culture Media Production

The Quadro Ytron® ZC Disperser is specifically designed to disperse extremely difficult-to-wet powders into a liquid stream in a single-pass.  Powder incorporation is achieved by the presence of significant vacuum in the reactor housing generated by the liquid seal created between the rotor and stator.  This vacuum ensures that powders from the hopper above are drawn into the reactor head, where the particles are subjected to intense mechanical shearing prior to hydration into the liquid stream.  The result is a homogeneous dispersion of the powders without “fish-eyes” or lumps, and minimal foaming.

To large multi-national biotech companies, the Quadro Ytron®  ZC Disperser offers a means to improve their production of cell culture media based solutions.  Conventional vortexing mixing methods used to incorporate powdered ingredients tend to have foaming issues with a percentage of the powdered ingredients becoming trapped in the foam, and not incorporated into the solution.  Batch times can exceed ten (10) hours as the agitation produced by the mixers is not enough to fully wet and de-agglomerate the ingredients.

The Quadro Ytron® ZC Disperser improves dispersion and wetting of the powdered ingredients and can reduce batch times to less than one (1) hour.

The Quadro Ytron® ZC Disperser is designed for clean-in-place and does not require disassembly or an external method for cleaning.  With the addition of our Uniform Film Interface (UFI) Feeding System, the ZC can be converted to operate continuously – 24/7 – at customer-specified powder and liquid incorporation rates.  This upgraded configuration is referred to as the Kontinuum Powder Disperser.

SOURCE: Quadro Engineering Corp.