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Article: Todays Issues Of Containment For Solid Dosage Production
When talking today about solid dosage form production, in 9 out of 10 cases containment immediately becomes one of the issues. Why? The first reason is that APIs are becoming more and more potent. According to an estimation by ISPE (Winter Conference Berlin 2002), by 2010 more than 85 % of all NCE will be classified potent (OEL < 10 µg/m³). The second reason is that health and safety authorities all around the world are putting more focus on the protection of operators dealing with these substances. The third reason is that suppliers of various hardware components have developed a huge variety of containment solutions, making it difficult to decide on the optimal solution, even for experienced people.
Before we look at the factors defining the required containment levels, and discussing the possible hardware solutions, some fundamental thoughts about containment need to be covered first.
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