Medicinal Chemistry & Lead Optimization

SCYNEXIS' medicinal chemistry group has a reputation equaling the best in the industry. Our team has the size and experience to handle projects of any complexity in a wide range of therapeutic areas. The Research Team leaders are knowledgeable scientists with years of industry experience. They coordinate and communicate key activities and drive resources to achieve success. The teams are enabled with SCYNEXIS' powerful proprietary technologies such as KIT™ Kinase Inhibitor Technology , HEOS® Software Suite and MEDCHEM-FACTORY®.

• HEOS® (Hit Explorer Operating System): Comprehensive web-based chemical information management software
• ADME/PK: Bioavailability, stability and Cyp450 information is available from our in-house capability
• KIT™ (Kinase Inhibitor Technology): Leverages structural information to define binding modes
• Computational Chemistry: Predictive physiochemical properties, homology modeling and receptor docking, QSAR
• MEDCHEM-FACTORY®: High-throughput synthesis and purification

Chemical Process Development & GMP Manufacturing

The SCYNEXIS Process Development team consists of approximately 25 scientific experts with an average of 20 years of industry experience. 12 of the team members hold Ph.D.'s and we maintain an even balance between process and analytical team members.

cGMP Manufacturing Suites & non-GMP Kilo Facilities:

• 3 separate GMP Suites
• Controlled access, dedicated air handling
• GMP Reactors: 25 L to 200 L QVF glass fixed reactors
• Huber chillers/heaters
• QA Audited, Expecting PAI in 2009
• Versatile non-GMP facilities
• Non-GMP Reactors: 20 L to 200 L QVF glass fixed reactors
• 6" Biotage chromatography systems

SCYNEXIS' Process Chemistry team has outstanding analytical support. We have in-house 400 and 500 MHz NMRs, LC-MS and LC-MS/MS, FT-IR, HPLC, GC, K-F, TOC and dedicated experts to assist in method development, validation and impurity identification.

Analytical Testing Services

Today's pharmaceutical environment demands rugged, sensitive and specific analytical methods to support FDA regulatory filings. SCYNEXIS has demonstrated success in developing and validating analytical methods for API's intended for Phase I clinical trials through NDA submission. We understand the API development industry and continually strive to meet our clients' most critical deadlines. Our team works in state-of-the-art facilities with access to a comprehensive suite of cutting edge analytical instrumentation. Highly sensitive genotoxic impurity methods have been developed for numerous clients and we have performed full API release testing for more than 50 programs. A broad array of analytical platforms and techniques is available:

Analytical service offerings include:

Bioanalytical & ADMET-PK Services SCYNEXIS provides rapid generation of reliable ADMET and pharmacokinetics (PK) on compounds with a focus on lead optimization integrated with medicinal chemistry teams. SCYNEXIS rapidly screens for properties including metabolic stability (complemented with specific CYP450 assays), permeability, transporters, protein binding and cytotoxicity to prioritize and optimize lead series based on ADMET properties. Secure timely web-based data exchange (HEOS®).

HEOS® Data Management & Collaboration Software

HEOS® suite is a comprehensive web-based Drug Research information management software that supports geographically distributed scientists and facilitate collaboration.

HEOS® is seamlessly integrated to "best" scientific expert software currently used in the Pharmaceutical Industry. It allows complex data (biology, chemistry, analytical, safety, PK...) to be exchanged, consolidated and shared rapidly and securely across multi-sites worldwide. It provides powerful searching capabilities to combine substructure and biological criteria, interactive SAR capabilities and decision tools to scientists and management.

Data Management:

• Comprehensive acquisition, organization and display of various types of information relevant to Drug Discovery projects: chemistry, analytical, biological assays, animal assays, ADME, Toxicology, Pharmacokinetics, etc.
• Powerful chemical-biological searching capabilities, including substructure searching
• Interactive SAR capabilities
• Flexible export to third-party software such as SpotFire for further data analysis

Collaboration:

• Secure access through a web interface with access-control to the data
• Easy publication of results from each project member
• Share decision-making reports
• Securely exchange key project documents