Material Handling Products & Services

1. Used Korsch PH103-DMS 3 Station Pharmaceutical Tablet Press 2/16/2024

   Used Korsch PH103-DMS tablet press, 3 station, 40 kN compression, 19 mm max tablet diameter, 15 mm max depth of fill, rated up to 270 tablets/minute, with parts, 1.8 kW motor, 220 volt, serial# 1.0025.93, built 1993.

2. Used 30" Vector Hi-Coater Tablet Coating Pan 2/15/2024

   30" Vector Hi-Coater Coating Pan, stainless steel construction, for model VHC-1355 coater, built 2002.

3. Used GlobePharma Single Station Pharmaceutical Tablet Press 2/15/2024

   Used GlobePharma Single Station Tablet Press.

4. Powder Flow Properties & Characterization Services 1/31/2024

   Basic Powder Flow Characterization [USP <1174>]:

   A powder flow analysis is an indicator of how well formulation will release from the hopper during the tableting. It is important to know that the developed formulation is showing ‘Mass Flow’ or ‘Funnel Flow’ or ‘Rat Holing’.

   Powder blend shows ‘Mass Flow’ when the entire solid bed is in motion during the discharge of material from the outlet. This is a ‘First-in-First-Out’ process. Hoppers offering ‘Mass Flow’ have steep and/or low-friction walls. This flow offers ‘No-Arching’, ‘Less Segregation’, and ‘Stable Powder Flow’.

   When the hopper is not sufficiently steep and smooth enough to ensure sliding along its wall, the powder blend exhibit ‘Funnel Flow’. Such hoppers are sensitive to arching and ratholing. In this case, powder discharge from the hopper is not predictable.

5. Oral Solid Dose Formulation Assessment Services 1/31/2024

   Send a test sample of your powder to Natoli Scientific to get your formula characterized following USP <1062> Guidelines (Tablet Characterization Methods) that we have been practicing for over 25 years.

6. Oral Solid Dose Formulation And Lab Scale Capabilities 1/31/2024

   Natoli Scientific is dedicated to developing high-quality affordable products for your market needs.

   We provide a formulation design based on a strong scientific understanding and decoding interplay of materials and process parameters to ensure product integrity. We use traditional as well as principles of ‘Quality by Design (QbD)’ to develop robust lead prototype formulations. The early sound scientific investment in product development saves time and money during scale-up and commercial manufacturing.

7. OSD Pharmaceutical Tablet Manufacturing Services For Clinical Trials 1/31/2024

   Natoli Scientific offers manufacturing services of oral solids at a pilot scale and drug products for clinical trials.

   We also offer full-scale commercial manufacturing service till you are ready with your own manufacturing facility to avoid delay in the commercial launch.

   Team Natoli understands the complexity of the tablet manufacturing process over more than half a century. We are ready to shoulder every step of the tablet manufacturing chain from blending to granulation, to milling, to compression, to coating. Our manufacturing capabilities are backed up by our expert scientific team, who are ready to offer guidance in product development, technical transfers, and scale-ups.

8. Pharmaceutical Preformulation Support Services 1/31/2024

   Partner with Natoli Scientific during the earliest stages. Our scientific expertise with state-of-the-art analytical capabilities is ready to take any preformulation challenge.

   Natoli scientific has an expertise of handling a wide range of APIs for the development of oral solids. We apply principles of ‘Quality by Design’ to define Critical Material Attributes (CMA), Critical Process Parameters (CPP), Critical Quality Attributes (CQA) and Quality Target Product Profiles (QTPP). Because we believe that understanding material and process as much as possible in the early life cycle of drug product development program is an insurance for further development path. Keeping your practices up to date with the ICHQ8 regulatory guidance issued by the US FDA. This is also a gate way for a smooth ride of product in the different stages of product development stages.

9. Oral Solid Dose Formulation Troubleshooting Support Services 1/31/2024

   Natoli organization is a reputed leader with more than a half century experience in the tablet manufacturing technology.

   We understand tablets better. We are here for serving your needs to overcome challenges associated with commercial manufacturing of solid dosage forms across the globe (North America, Europe, Asia).

   Our Natoli scientific team uses holistic approach to understand and solve important tableting problems like capping, lamination, picking, and sticking. We integrate scientific information gathered at material, process, and instrument level to understanding and decode root causes of these common tableting issues.

10. Pharmaceutical Tablet Presses 1/31/2024

    Natoli’s line of affordable tablet presses is designed, engineered, and manufactured in the U.S.A. and built on our decades of experience in the tableting industry. We know our customers want presses that efficiently meet their R&D and/or production needs.

    With Natoli you have a choice in your tablet press: R&D or production, single-station or rotary, fully automated or manual. Whatever your need, Natoli’s best-in-class tablet presses can help you optimize tablet quality while saving time and reducing costs.