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Enteric Coatings
Evonik Röhm GmbH•Datasheet: Enteric Coatings
Many pharmaceutical dosage forms irritate the stomach due to their chemical properties. Others undergo chemical changes in gastric acid and through the action of enzymes, thus becoming less effective.
The EUDRAGIT® grades for enteric coatings are based on anionic polymers of methacrylic acid and methacrylates. They contain –COOH as a functional group. They dissolve at ranges from pH 5.5 to pH 7. The different products are available as aqueous dispersions, powders and organic solvents.
|
Applications |
EUDRAGIT®
Grades |
Availability |
Functionality |
Dissoltion Properties |
Monographs
+ DMFs |
|
Drug delivery in duodenum |
EUDRAGIT® L 100-55 EUDRAGIT® L 30 D-55 |
Powder Aqueous dispersion 30% |
Anionic polymers with methacrylic acid as a functional group |
Dissolution above pH 5.5 |
Ph.Eur., USP/NF, JPE, DMF 2548 Ph.Eur., USP/NF, JPE, DMF 2584 |
|
Drug delivery in jejunum |
EUDRAGIT® L 100 |
Powder |
Dissolution above pH 6.0 |
Ph.Eur., USP/NF, JPE, DMF 1242 |
|
|
Drug delivery in ileum |
EUDRAGIT® S 100 |
Powder |
Dissolution above pH 7.0 |
Ph.Eur., USP/NF, JPE, DMF 1242 |
|
|
Colon delivery |
EUDRAGIT® FS 30 D |
Aqueous dispersion 30% |
DMF 13941 |
Application benefits of enteric EUDRAGIT® coatings:
- PH-dependent drug release
- Protection of actives sensitive to gastric fluid
- Protection of gastric mucosa from aggressive actives
- Increase in drug effectiveness
- Good storage stability
- GI and colon targeting
•Datasheet: Enteric Coatings
