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BioSepra Heparin HyperD® M composite chromatography sorbent is the most technologically advanced high speed, high capacity affinity preparative sorbents for the purification of biological molecules that bind to heparin, such as coagulation factors, growth factors, lipoproteins... The sorbent provides high binding capacity at high flow rates.

Heparin HyperD M unique composite structure was chosen to provide superior dynamic capacity at high linear velocities. HyperD sorbent is comprised of a porous rigid mineral bead containing heparin bound hydrogel filled pores. BioSepra holds U.S. patent 5,268,097 (1993) covering the unique properties of HyperD sorbents and U.S. patent 5,234,991 (1987) on other "supported gel" or "œgel-in-a-shell" sorbents.

Heparin HyperD M has an average particle size of 80 µm and is used for preparative scale purification of ATIII. The sorbent can be packed in column sizes from ml to more than hundred liters and operated at high flow rates with low backpressure.

The main benefits of Heparin HyperD M sorbent are:

• Rapid packing due to the high density of heparin sorbent which settles in a few minutes.
• HyperD sorbent is very rigid and allows the use of high flow rates without pressure increase or shrinking or swelling of the sorbent.
• Heparin leakage is minimized due to the stable chemical link of the heparin molecule to the sorbent.