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•Datasheet: Mustang Chromatography Capsules And Cartridges

Combining high-capacity ion-exchange Mustang® membranes with a unique 16-layer pleat design results in high flow rate, high-capacity, single-use, versatile, range of pleated products that can be used for a wide range of applications. This 16-layer construction is held constant from the laboratory scale Mustang Coin Unit to the largest industrial process scale capsule, ensuring constant chromatography bed depth in all formats.

The recent introduction of the 5L Mustang XT capsules represent a quantum leap in the era of membrane chromatography, and makes membrane chromatography an excellent option for the capture of large biomolecules.

Mustang E capsules use three layers of a standard pleat format membrane to remove endotoxin from process feedstreams. The 3-layer construction is held constant from the Mustang E Acrodisc format to the largest industrial process scale capsule.

The ease of linear scale-up ensures a shortened process development time by significantly reducing the re-optimization required between scale up steps. These units are specifically designed to be single-use. This eliminates cleaning and the costs associated with cleaning validation. Mustang capsules are fully self contained units that connect directly into a system using sanitary flange connectors.

Mustang Q Membrane

Mustang Q membrane is an anion exchange support with pendant quaternary amine functional groups in a cross-linked polymeric coating on a 0.8 µm pore size polyethersulfone membrane. This gives high dynamic capacities for high molecular weight products such as DNA, plasmids or even particles as large as viruses.

Mustang S Membrane

Mustang S membrane is a cation exchange support with pendant sulfonic functional groups in a cross-linked polymeric coating on a 0.8 µm polyethersulfone pore size membrane. This gives high dynamic capacities for high molecular weight products such as IgG, Factor VIII and some viruses.

Mustang E Membrane

Mustang E membrane is a highly cross-linked quaternized amine charge polymer coating based on polyethyleneimine on a 0.2 µm polyethersulfone pore size membrane. This gives very high dynamic capacities under selected conditions for the removal of endotoxin from process feedstreams, buffers, and water

Features and Benefits

• Binding Efficiency — Charged biomolecules are readily bound in a single pass
• Speed — High-flow rates enable the processing of large volumes in less than a single working shift. Mustang units typically operate at flow rates between 10 to 40 membrane volumes per minute, making them much faster than a conventional chromatography resin
• Scalability — A full range of sizes accommodates the different volumes and capacities required in BioPharmaceutical processing.
• Convenience — Ready to use, autoclavable and disposable to eliminate potential packing, cleaning, validation and cross-contamination issues
• Flexible — Available in capsule or cartridge format
• Cost — Lower operating costs and capital investment compared to conventional columns that need validated pack¬ing and cleaning

Applications

Contaminant removal with Mustang Q, S, and E capsules

• DNA
• Viruses
• HCP
• Endotoxins

Biomolecule capture with Mustang XT capsules

• Antisense oligonucleotides
• Vaccines
• Gene therapy vectors
• Clotting factors
• Antibodies
• Recombinant proteins

Click Here To Download:
•Datasheet: Mustang Chromatography Capsules And Cartridges