Fundamentals Of Spray-Dried Dispersion Technology
A common problem statement in the pharmaceutical industry is low oral bioavailability of drug candidates with poor aqueous solubility. The literature suggests that a significant majority of new drug candidates are in the Biopharmaceutics Classification System (BCS) class II and IV space, which includes compounds that are dissolution rate, solubility or permeability limited to absorption, or all three. As portfolios across the industry are increasingly focused on these compounds, the need for enabling technologies continues to grow.
WHITE PAPERS & CASE STUDIES
Fluid Bed System Triples Batch Sizes for Laboratorios Normon while Reducing Costs
With the aim of reducing costs, Normon planned to significantly increase its batch sizes for certain products. The manufacturer needed to pay close attention to the high quality and safety standards and economic aspects, as well as flexible production sizes and times.
Efficiencies In Powder Dispersion For Manufacturers
This white paper explores five tips for dispersing powders into liquid more efficiently.
Medication Errors -- A Threat To Patient Safety: Mitigating Errors With Tablet Appearance
Medical prescription drug errors by doctors, pharmacists and patients account for 1.5 million incidences of sickness, injuries or deaths in the U.S. each year. By Jay Anbil and Steve Yoder
Film Coating For Pediatric Oral Solid Dosage Forms
From a recent survey conducted within the pharmaceutical industry, by Colorcon, it was confirmed that oral solid dosage forms are a preferred choice for formulation of pediatric medicines.
Accelerating Lipid-Based Drug Formulation Through Application Of An Expert System
Formulation scientists have become pivotal to pharmaceutical development, in that they are often faced with the daunting challenge of not only identifying the most suitable drug delivery platform among a myriad of options, but also developing and validating robust systems that address the challenges posed by increasingly complex drug candidates, in ever shortening time frames. By Eduardo Jule, Ph.D., Senior Manager, Formulation and Pharmaceutical Development
When Capsules Fall Apart, Who Is To Blame?
Capsule integrity is a given for established manufacturers with impeccable reputations. Consumers, however, know from experience that not all capsules are made equal. Some can be difficult to extract from the blister pack. Others may have gel caps with cracks or, even worse, ruptures that allow the ingredients to spill out. Is this a manufacturing problem? Or has R&D neglected to implement a fool proof test methodology for evaluating capsule stability? Compression and tension testing offer a technical approach with quantifiable results that can be used to assess capsule performance.