Comparative Evaluation Of Automated Flash Chromatography And Preparative HPLC For Bench-Scale Purification Of A Broad Range Of Sample Types
The goal of a purification chemist is to deliver suitable quantities of high purity compounds in the shortest possible time. Two of the most popular purification techniques are Automated Flash Column Chromatography (AFCC) and Preparative HPLC. Traditionally, AFCC is characterized by the ability to load large amounts of material and has short purification times, while Prep HPLC is valued for high resolution separations resulting in very pure products. As a result, AFCC is often used as a preliminary technique whereby the crude sample is pre-purified before final high resolution purification using Prep HPLC. By Bopanna N.K., Chitra Sundararajan, and Mark Jacyno
WHITE PAPERS & CASE STUDIES
QC Testing: Quality Control Methods That Make A Difference
By Robert McGregor, Global Marketing and High End Product Manager, Brookfield Engineering Laboratories, Inc.
How do you bring consistency to QC testing? Pharmaceutical products that meet manufacturability criteria and provide high level consumer satisfaction undergo a battery of tests before being distributed to the consumer. Using affordable instrumentation to perform QC tests, which certify that tablets, capsules, elixirs, ointments, etc. have the right physical properties, is essential for today’s successful business.
Ribbon Blenders: A Best Practices Guide
This white paper presents some basic best practices for efficient processing in a Ribbon Blender. The ideas discussed here are recommendations based on practical and technical experience gained by Ross over several decades as a leading supplier of Ribbon Blenders to the process industries worldwide.
Custom Powder Systems Announces Dramatic Yield Increase Through Use Of Anti-Segregation Technologies
A unique solution improves yields from less than 75% to over 98%.
Blender Type Comparison: Pedestal Blender (PB) vs. Column Blender (CB)
A pedestal blender is a single purpose machine that can only blend. A column blender has the additional capability a lifting axis and slew (placing) axis that offers the additional capabilities.
Accelerating Lipid-Based Drug Formulation Through Application Of An Expert System
Formulation scientists have become pivotal to pharmaceutical development, in that they are often faced with the daunting challenge of not only identifying the most suitable drug delivery platform among a myriad of options, but also developing and validating robust systems that address the challenges posed by increasingly complex drug candidates, in ever shortening time frames. By Eduardo Jule, Ph.D., Senior Manager, Formulation and Pharmaceutical Development
Rupture Test: A Quick and Easy Way to Avoid Soft Gel Capsule Failure
When soft gel capsules rupture during production, packaging or subsequent handling, the damage is oftentimes more extensive than just the single capsule that fails. When consumed by patients, if the active ingredients in soft gel capsules fail to escape as designed at the appropriate time (by rupture, dissolution, or melting), then the product is a failure. Both types of problems are due to non-conforming capsule film strength. How can you predict these types of problems before they occur? Performing a simple rupture test is the quickest way to avoid these potential disasters.
By Eric Chiang, Product Manager, Brookfield