Formulation Development

FORMULATION DEVELOPMENT WHITE PAPERS & ARTICLES

  • 4 Questions To Guide Your Laboratory Centrifuge Selection
    4 Questions To Guide Your Laboratory Centrifuge Selection

    A centrifuge is an integral component of a laboratory that is critical to the success of an analysis. They come in a variety of sizes, from mini-centrifuges that hold only a few small tubes and spin a few thousand RPM to high capacity centrifuges that hold up to 6 liters of samples to ultracentrifuges that spin upwards of 100,000 RPM. Multiple options in size as well as other areas can make choosing the right centrifuge for your application an overwhelming task.

  • Scientific Advances Address Challenges Posed By Poor Solubility Of Drug Candidates
    Scientific Advances Address Challenges Posed By Poor Solubility Of Drug Candidates

    At Metrics Contract Services, Dr. Michael DeHart manages all aspects of personnel and operations relating to formulating and manufacturing a client’s pharmaceutical materials for Phase I, II and III clinical trials. In this article, Dr. DeHart discusses how scientific advances are addressing challenges posed by the poor solubility or stability of drug candidates.

  • How Broadening The Analysis Of Compound Factors Allows For Predictive Solubility Solutions
    How Broadening The Analysis Of Compound Factors Allows For Predictive Solubility Solutions

    The Biopharmaceutics Classification System (BCS), developed by the U.S. Food and Drug Administration to simplify and accelerate the drug development process, helps companies when they file for bioequivalence of dosage forms based on in vitro dissolution testing. The objective of the BCS system is to predict in vivo performance of drugs from in vitro measurements of solubility and permeability. The system has evolved to classify low-soluble drugs according to their permeability (BCS Class II or IV). A compound’s classification (I through IV) is indicative of its potential bioavailability.

  • Anticipating The Formulation Challenges Of Complex Molecules
    Anticipating The Formulation Challenges Of Complex Molecules

    If formulation problems surface late in the process of turning active pharmaceutical ingredients (APIs) into beneficial drug products, developers may have to go back and change their API production processes. In the worst cases, Phase 1 and Phase 2 trials may have to be redone. And due to the increasing complexity of today’s API molecules, formulation problems are arising with greater frequency, delaying development, and burdening developers with unanticipated and heavy costs.

  • Streamlining Recombinant Protein Production
    Streamlining Recombinant Protein Production

    Use of recombinant proteins as therapeutics has become an attractive strategy for altering the biology of disease progression and offers significant commercial opportunities.  However, bringing a recombinant protein to market requires a substantial investment of time and resources, and the process is generally complex and subject to technical pitfalls.

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FORMULATION DEVELOPMENT APPLICATIONS & STUDIES

  • How A Placebo Formulation Is Designed For An Oral Solid Dose Product
    How A Placebo Formulation Is Designed For An Oral Solid Dose Product

    To demonstrate the process by which a placebo formulation was designed for an oral solid dose product that would be dispensed to the patient as a fast-dissolve tablet.  The tablet is added to water and the resulting solution is dosed as a antibiotic mouthwash.   Placebo matching was required not only for the tablet but also for the solution which the patient took.

  • Improving Suspendibility Of A Water- Insoluble API For Oral Suspension
    Improving Suspendibility Of A Water- Insoluble API For Oral Suspension

    To improve the suspendibility of a water- insoluble active pharmaceutical ingredient (API) in a sorbitol- based reconstitutable powder for oral suspension formulation using two novel excipients Sentry™Polyox™WSR N80, NF (polyethylene oxide) and Avicel CL-611® NF (microcrystalline cellulose/carboxymethylcellulose sodium).

  • Predicting The Fate Of Crosslinked Gelatin Capsules In Gastrointestional Milieu
    Predicting The Fate Of Crosslinked Gelatin Capsules In Gastrointestional Milieu

    To observe, using carbon-13 nuclear magnetic resonance (13C-NMR), the effect of dilute acid and pepsin on gelatin crosslinks, induced by addition of 13C-enriched formaldehyde (13CH2O) to an aqueous gelatin solution.

  • How To Optimize Your Weighing Process
    How To Optimize Your Weighing Process

    Many factors found in the laboratory can influence the behavior of a balance. Learn how to anticipate and regulate them to achieve the ideal settings for your balance and the most reliable weighing results. By Michelle Sheridan, Sales Specialist, Premium Weighing Sartorius Corporation

  • A Mesoporous Silica Carrier Optimized For Liquisolid And Lipid-Based Formulations
    A Mesoporous Silica Carrier Optimized For Liquisolid And Lipid-Based Formulations

    Syloid® XDP silicas are mesoporous, amorphous, silica gel excipients with a unique morphology that create an excellent solid porous carrier for pharmaceutical formulations. The combined adsorption capacity, porosity, particle size, and density provides a tool to create formulations which can expedite manufacturing and improve efficacy of the final dosage form.

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FORMULATION DEVELOPMENT PRODUCTS & SERVICES

Syloid® FP Silica Excipients Syloid® FP Silica Excipients

Syloid® FP silicas are the intelligent choice for many pharmaceutical applications due their unique morphology. The combined adsorption capacity, porosity, particle size, and greater internal surface area allow it to provide several benefits simultaneously that can help minimize the number of excipients required, expedite manufacturing, and improve efficacy of the final dosage form.

Laboratory Centrifuges Laboratory Centrifuges

NuAire benchtop centrifuges offer mono and multi functionality, refrigerated and non-refrigerated models. Technical innovations optimize productivity in your laboratory work to improve results, save time, while providing a greater relative centrifugal force (RFC).

High-Speed Refrigerated Centrifuge High-Speed Refrigerated Centrifuge

The Hitachi Koki model himac CR22N High-Speed Refrigerated Centrifuge offers reliable performance with a maximum RCF of 55,200xg and capacity of 6L for bottles, tubes, or microplates. Patented features such as the Automatic Rotor Identification and Rotor Cover Detector make the CR22N the ideal separation tool for multiple research applications involving DNA, RNA, viruses, proteins, and more

CR22N High-Speed Refrigerated Centrifuge CR22N High-Speed Refrigerated Centrifuge

The Hitachi Koki model himac CR22N High-Speed Refrigerated Centrifuge offers reliable performance with a maximum RCF of 55,200xg and capacity of 6L for bottles, tubes, or microplates. Patented features such as the Automatic Rotor Identification and Rotor Cover Detector make the CR22N the ideal separation tool for multiple research applications involving DNA, RNA, viruses, proteins, and more.

Used Pharmacia Biotech Chromatography Column Used Pharmacia Biotech Chromatography Column

One (1) used Pharmacia Biotech chromatrography column, column type 450V-200-400, stainless steel product contact surfaces, 31.8-63.6 lier capacity, rated 3 bar at 2 - 30 C, serial# 450V-EQ434-01, with pump cart with (2) 1" poly diaphragm pumps, vessel certified by Mann Welding, rated 45 psi and full vacuum at 100 F, on cart, serial# 1778, national board# 1364, built 1997.

Used Sartorius 200 Liter Fermenter Used Sartorius 200 Liter Fermenter

One (1) used 200 liter (52.84 gallon) Sartorius fermeter system, model 200 LDP, stainless steel construction, approximately 24" diameter x 36" straight side, hinged dish top, dish bottom, rated 40 psi and full vacuum at 300 f internal, jacketed for 60 psi and full vacuum at 325 f, bottom entering agitator drive, 1 hp, 208-230 volt with prop style agitator, skid mounted on load cells with Sartorius PLC controls, with vfd for agitator, vessel certified by Lee, serial# 42192-1, national board# 10482, new 2006

Micro Ultracentrifuges Micro Ultracentrifuges

NuAire is pleased to partner with the reputable brand Hitachi Koki to offer our customers sales and support of table top and floor standing Mirco Ultracentrifuges in the North American market.

Used IKA Magic Lab Mixer Used IKA Magic Lab Mixer

One (1) used IKA powder liquid mixer, model Magic Lab, 316 stainless steel construction, .9 kw motor, 220 volt motor, serial# U078310.

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