The Micro-Innovators Small Enterprises Make Outsized Contributions With Novel Drugs
Small companies developing novel drugs have many challenges and obstacles, however, those that are successful can teach us valuable lessons in how to survive in the world of medicine.
WHITE PAPERS & CASE STUDIES
Why Can’t I Use Bacon Fat In My Drug Product Formulation?
If there were a bar where all of the hip drug product formulators hung out at the end of a hard day of formulating, two things would be certain, the beers on tap would be from breweries like Avery, Greenflash, and Dogfish Head rather than Coors, Miller, and Anheuser Busch, and all of the jokes would be about discovery guys. By Bruce Rehlaender, Ph.D., Principal, Formulation Development, PharmaDirections, Inc.
Challenges & Opportunities: Encapsulation Of Liquid & Semi-Solid Formulations Into Oral Capsules
The encapsulation of liquids and semi-solids provides solutions for convenient delivery through improved oral absorption of poorly water-soluble drugs.
Accelerating Lipid-Based Drug Formulation Through Application Of An Expert System
Formulation scientists have become pivotal to pharmaceutical development, in that they are often faced with the daunting challenge of not only identifying the most suitable drug delivery platform among a myriad of options, but also developing and validating robust systems that address the challenges posed by increasingly complex drug candidates, in ever shortening time frames. By Eduardo Jule, Ph.D., Senior Manager, Formulation and Pharmaceutical Development
AMRI Pharmaceutical Development Case Studies
AMRI offers integrated pharmaceutical development services from API development; preformulation and material science; formulation development; Clinical Trial Material (CTM) manufacturing; Chemistry, Manufacturing, and Control (CMC)-enabling analytical development; and regulatory affairs services for investigational new drug (IND) / investigational medicinal product dossier (IMPD) filing.
Improving Drug Delivery Systems With Novel Emulsion Technologies For Sterile Product Formulation
ET4ME type technologies address head on the challenges of large-scale manufacturing/scale-up needs and convoluted production schemes. Polymer microspheres can be formulated with a highly defined size, encapsulating the API in a polymer matrix.
Novel Controlled Release Formulation For Orally Disintegrating Tablets Using Ion Exchange Resins
Oral disintegrating tablets (ODTs) are designed to disintegrate rapidly in the mouth upon contact with saliva (≤ 30 seconds) and allow oral drug delivery without chewing or a need for water. By Abhijit Gokhale and Praba Sundararajan, Pharmaceutical Development Services, Patheon Pharmaceuticals Inc.