People expect options in most areas of their lives, so why should their medication be any different?
Swallowing tablets or capsules is difficult for many, and size is just one of the problems.
A significant share of current drug development pipelines include active pharmaceutical ingredients (APIs) that fall into BCS (biopharmaceutical classification system) 2 and 4 spaces. These compounds are typically characterized by their lowaqueous solubility and thus poor bioavailability, requiring advanced formulation approaches. Various approaches have been developed to enable these types of compounds, including particle size reduction (eg, micronization), chemical modification (eg, salt forms and pro-drugs), complexing agents, solubilized liquid forms (eg, SEDDS), and solid amorphous dispersions.
The pharmaceutical industry has undergone a sea of change in recent years as manufacturers have adapted to the end of the era of large-volume production of mass-market blockbuster drugs. With firms now focusing in on subpopulations of patients, there is a need for lean, adaptable facilities that can switch quickly between multiple products in multiple formats. Modular facilities can meet this need. While not a panacea, for the right project characteristics, ‘Modularity in Design’ can deliver significant and quantifiable long-term value.
Analytical laboratories have to provide sound results in a short time. Speed and reproducibility play a significant role here. Modern automation technology saves time, increases quality and reduces costs for the transport and distribution of samples. Ready-to-install subsystems from Festo are opening up new possibilities for efficient processes in laboratory automation.
Many factors found in the laboratory can influence the behavior of a balance. Learn how to anticipate and regulate them to achieve the ideal settings for your balance and the most reliable weighing results. By Michelle Sheridan, Sales Specialist, Premium Weighing Sartorius Corporation
Syloid® XDP silicas are mesoporous, amorphous, silica gel excipients with a unique morphology that create an excellent solid porous carrier for pharmaceutical formulations. The combined adsorption capacity, porosity, particle size, and density provides a tool to create formulations which can expedite manufacturing and improve efficacy of the final dosage form.
Carbohydrates present a particular detection challenge because they lack chromophores. The traditional approaches to carbohydrate detection are either differential refractive index (RI) or low-wavelength UV (190 – 205nm).
The Danish Pharmaceutical Group Novo Nordisk has chosen Bürkert, the fluid control specialists, to equip its latest production line for the formulation of insulin vials at its site in Chartres (Eure-et-Loir), France. A technical solution supported by Bürkert allows the pharmaceutical leader to simplify their processes and increase productivity.
Handling HP/C compounds requires highly specialized facilities and controls. As part of Pharmatek’s overall corporate safety program, they chose to integrate ILC Dover Flexible Containment Solutions into their HP/C facilities.