Formulation Development

FORMULATION DEVELOPMENT WHITE PAPERS & ARTICLES

  • Understanding What Patients Want In A Medicine
    Understanding What Patients Want In A Medicine

    People expect options in most areas of their lives, so why should their medication be any different?

  • Why Size Matters When It Comes To Taking Medicine
    Why Size Matters When It Comes To Taking Medicine

    Swallowing tablets or capsules is difficult for many, and size is just one of the problems.

  • Manufacturing Spray-Dried Dispersions: Process Control Strategies
    Manufacturing Spray-Dried Dispersions: Process Control Strategies

    A significant share of current drug development pipelines include active pharmaceutical ingredients (APIs) that fall into BCS (biopharmaceutical classification system) 2 and 4 spaces. These compounds are typically characterized by their lowaqueous solubility and thus poor bioavailability, requiring advanced formulation approaches. Various approaches have been developed to enable these types of compounds, including particle size reduction (eg, micronization), chemical modification (eg, salt forms and pro-drugs), complexing agents, solubilized liquid forms (eg, SEDDS), and solid amorphous dispersions.

  • Modular Facility Design: A Cost-Effective Option In The Post-Blockbuster Drug Era
    Modular Facility Design: A Cost-Effective Option In The Post-Blockbuster Drug Era

    The pharmaceutical industry has undergone a sea of change in recent years as manufacturers have adapted to the end of the era of large-volume production of mass-market blockbuster drugs. With firms now focusing in on subpopulations of patients, there is a need for lean, adaptable facilities that can switch quickly between multiple products in multiple formats. Modular facilities can meet this need. While not a panacea, for the right project characteristics, ‘Modularity in Design’ can deliver significant and quantifiable long-term value.

  • Ready-To-Install Laboratory Automation Systems For Efficient Laboratory Processes
    Ready-To-Install Laboratory Automation Systems For Efficient Laboratory Processes

    Analytical laboratories have to provide sound results in a short time.  Speed and reproducibility play a significant role here.  Modern automation technology saves time, increases quality and reduces costs for the transport and distribution of samples.  Ready-to-install subsystems from Festo are opening up new possibilities for efficient processes in laboratory automation.

More From Formulation Development White Papers & Articles

FORMULATION DEVELOPMENT APPLICATIONS & STUDIES

  • How To Optimize Your Weighing Process
    How To Optimize Your Weighing Process

    Many factors found in the laboratory can influence the behavior of a balance. Learn how to anticipate and regulate them to achieve the ideal settings for your balance and the most reliable weighing results. By Michelle Sheridan, Sales Specialist, Premium Weighing Sartorius Corporation

  • A Mesoporous Silica Carrier Optimized For Liquisolid And Lipid-Based Formulations
    A Mesoporous Silica Carrier Optimized For Liquisolid And Lipid-Based Formulations

    Syloid® XDP silicas are mesoporous, amorphous, silica gel excipients with a unique morphology that create an excellent solid porous carrier for pharmaceutical formulations. The combined adsorption capacity, porosity, particle size, and density provides a tool to create formulations which can expedite manufacturing and improve efficacy of the final dosage form.

  • Challenges Of Carbohydrate Analysis And Purification

    Carbohydrates present a particular detection challenge because they lack chromophores. The traditional approaches to carbohydrate detection are either differential refractive index (RI) or low-wavelength UV (190 – 205nm).

  • A New Formulation Line for Insulin Vials

    The Danish Pharmaceutical Group Novo Nordisk has chosen Bürkert, the fluid control specialists, to equip its latest production line for the formulation of insulin vials at its site in Chartres (Eure-et-Loir), France. A technical solution supported by Bürkert allows the pharmaceutical leader to simplify their processes and increase productivity.

  • Process Train Containment In CMO Operations

    Handling HP/C compounds requires highly specialized facilities and controls. As part of Pharmatek’s overall corporate safety program, they chose to integrate ILC Dover Flexible Containment Solutions into their HP/C facilities.

More From Formulation Development Applications & Studies

FORMULATION DEVELOPMENT PRODUCTS & SERVICES

Ultracentrifuge Ultracentrifuge

The CP100WX is a general-purpose Ultracentrifuge with outstanding performance up to 100,000 rpm assisting in a wide range of separation protocols in involving proteins, DNA, RNA, metal nano-colloids, and more. Reliable and efficient the Hitachi CP100WX features a Rotor Life Management (RLM) system to automatically maintain rotor logging history maximizing rotor life.

Used New Brunswick 80 Liter Fermenter Used New Brunswick 80 Liter Fermenter

One (1) used 80 liter New Brunswick fermenter, model MPPF.80L, stainless steeel construction, rated 40 psi at 300 f internal, jacketed for 35 psi at 300 f, under driven agitator, flat top, dish bottom, MFG# M1153-0002, vessel serial# 1577, national board# 1577, machine serial# 784407158, built 1987.

CR22N High-Speed Refrigerated Centrifuge CR22N High-Speed Refrigerated Centrifuge

The Hitachi Koki model himac CR22N High-Speed Refrigerated Centrifuge offers reliable performance with a maximum RCF of 55,200xg and capacity of 6L for bottles, tubes, or microplates. Patented features such as the Automatic Rotor Identification and Rotor Cover Detector make the CR22N the ideal separation tool for multiple research applications involving DNA, RNA, viruses, proteins, and more.

Used New Brunswick 500 Liter Fermenter Used New Brunswick 500 Liter Fermenter

One (1) used 500 liter New Brunswick fermenter, 316 stainless steel construction, rated 40 psi at 300 f internal, 304 stainless steel jacket rated 35 psi at 300 f, top entering 5 hp 230/460 volt agitator drive with 3 tier 6 blade paddle agitator, baffles, motorized top agitator lift driven by 1/3 hp 115 volt motor, on legs, serial# 1581, national board# 1377, built 1987.

VirTis BenchTop Pro Freeze Dryer with Omnitronics VirTis BenchTop Pro Freeze Dryer with Omnitronics

The VirTis BenchTop Pro freeze dryers have been designed to meet the needs of the most demanding research laboratories. Each system can be configured to meet your present and future needs. Condenser refrigeration packages of -55°C, -75°C, -85°C and -105°C can meet the demands of both aqueous or aqueous-solvent based formulations.

Used Huttlin Pharma Fluid Bed Coater Used Huttlin Pharma Fluid Bed Coater

One (1) used Huttlin Coater, stainless steel and glass construction, spray nozzle, electrically heated with air handling unit with blower on stand with controls.

Used Accela 60” Coating Pan Used Accela 60” Coating Pan

One (1) used Thomas Engineering Accela Cota coating pan, model 60D, 60" diameter perforated pan, with spray guns, controls, serial# 60-847.

Used Arrow Lab Mixer Used Arrow Lab Mixer

Used Arrow air drive lab size mixer with shaft and prop.

More From Formulation Development Products & Services