Formulation Development

FORMULATION DEVELOPMENT WHITE PAPERS & ARTICLES

  • Streamlining Recombinant Protein Production
    Streamlining Recombinant Protein Production

    Use of recombinant proteins as therapeutics has become an attractive strategy for altering the biology of disease progression and offers significant commercial opportunities.  However, bringing a recombinant protein to market requires a substantial investment of time and resources, and the process is generally complex and subject to technical pitfalls.

  • Understanding What Patients Want In A Medicine
    Understanding What Patients Want In A Medicine

    People expect options in most areas of their lives, so why should their medication be any different?

  • Why Size Matters When It Comes To Taking Medicine
    Why Size Matters When It Comes To Taking Medicine

    Swallowing tablets or capsules is difficult for many, and size is just one of the problems.

  • Manufacturing Spray-Dried Dispersions: Process Control Strategies
    Manufacturing Spray-Dried Dispersions: Process Control Strategies

    A significant share of current drug development pipelines include active pharmaceutical ingredients (APIs) that fall into BCS (biopharmaceutical classification system) 2 and 4 spaces. These compounds are typically characterized by their lowaqueous solubility and thus poor bioavailability, requiring advanced formulation approaches. Various approaches have been developed to enable these types of compounds, including particle size reduction (eg, micronization), chemical modification (eg, salt forms and pro-drugs), complexing agents, solubilized liquid forms (eg, SEDDS), and solid amorphous dispersions.

  • Modular Facility Design: A Cost-Effective Option In The Post-Blockbuster Drug Era
    Modular Facility Design: A Cost-Effective Option In The Post-Blockbuster Drug Era

    The pharmaceutical industry has undergone a sea of change in recent years as manufacturers have adapted to the end of the era of large-volume production of mass-market blockbuster drugs. With firms now focusing in on subpopulations of patients, there is a need for lean, adaptable facilities that can switch quickly between multiple products in multiple formats. Modular facilities can meet this need. While not a panacea, for the right project characteristics, ‘Modularity in Design’ can deliver significant and quantifiable long-term value.

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FORMULATION DEVELOPMENT APPLICATIONS & STUDIES

  • How A Placebo Formulation Is Designed For An Oral Solid Dose Product
    How A Placebo Formulation Is Designed For An Oral Solid Dose Product

    To demonstrate the process by which a placebo formulation was designed for an oral solid dose product that would be dispensed to the patient as a fast-dissolve tablet.  The tablet is added to water and the resulting solution is dosed as a antibiotic mouthwash.   Placebo matching was required not only for the tablet but also for the solution which the patient took.

  • Improving Suspendibility Of A Water- Insoluble API For Oral Suspension
    Improving Suspendibility Of A Water- Insoluble API For Oral Suspension

    To improve the suspendibility of a water- insoluble active pharmaceutical ingredient (API) in a sorbitol- based reconstitutable powder for oral suspension formulation using two novel excipients Sentry™Polyox™WSR N80, NF (polyethylene oxide) and Avicel CL-611® NF (microcrystalline cellulose/carboxymethylcellulose sodium).

  • Predicting The Fate Of Crosslinked Gelatin Capsules In Gastrointestional Milieu
    Predicting The Fate Of Crosslinked Gelatin Capsules In Gastrointestional Milieu

    To observe, using carbon-13 nuclear magnetic resonance (13C-NMR), the effect of dilute acid and pepsin on gelatin crosslinks, induced by addition of 13C-enriched formaldehyde (13CH2O) to an aqueous gelatin solution.

  • How To Optimize Your Weighing Process
    How To Optimize Your Weighing Process

    Many factors found in the laboratory can influence the behavior of a balance. Learn how to anticipate and regulate them to achieve the ideal settings for your balance and the most reliable weighing results. By Michelle Sheridan, Sales Specialist, Premium Weighing Sartorius Corporation

  • A Mesoporous Silica Carrier Optimized For Liquisolid And Lipid-Based Formulations
    A Mesoporous Silica Carrier Optimized For Liquisolid And Lipid-Based Formulations

    Syloid® XDP silicas are mesoporous, amorphous, silica gel excipients with a unique morphology that create an excellent solid porous carrier for pharmaceutical formulations. The combined adsorption capacity, porosity, particle size, and density provides a tool to create formulations which can expedite manufacturing and improve efficacy of the final dosage form.

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FORMULATION DEVELOPMENT PRODUCTS & SERVICES

Used  365 LCMS/MS SCIEX Mass Spectrometer Used 365 LCMS/MS SCIEX Mass Spectrometer

One (1) used SCIEX API mass spectrometer, model 365 LCMS/MS.

Used IKA Magic Lab Mixer Used IKA Magic Lab Mixer

One (1) used IKA powder liquid mixer, model Magic Lab, 316 stainless steel construction, .9 kw motor, 220 volt motor, serial# U078310.

Benchtop Centrifuges Benchtop Centrifuges

NuAire benchtop centrifuges offer mono and multi functionality, refrigerated and non-refrigerated models. Technical innovations optimize productivity in your laboratory work to improve results, save time, while providing a greater relative centrifugal force (RFC).

Microcentrifuge Microcentrifuge

NuAire offers ventilated and refrigerated micro-centrifuges ideal for high and low speed applications for small sample volumes.

Used Accela 60” Coating Pan Used Accela 60” Coating Pan

One (1) used Thomas Engineering Accela Cota coating pan, model 60D, 60" diameter perforated pan, with spray guns, controls, serial# 60-847.

Used New Brunswick 500 Liter Fermenter Used New Brunswick 500 Liter Fermenter

One (1) used 500 liter New Brunswick fermenter, 316 stainless steel construction, rated 40 psi at 300 f internal, 304 stainless steel jacket rated 35 psi at 300 f, top entering 5 hp 230/460 volt agitator drive with 3 tier 6 blade paddle agitator, baffles, motorized top agitator lift driven by 1/3 hp 115 volt motor, on legs, serial# 1581, national board# 1377, built 1987.

High-Speed Refrigerated Centrifuge High-Speed Refrigerated Centrifuge

The Hitachi Koki model himac CR22N High-Speed Refrigerated Centrifuge offers reliable performance with a maximum RCF of 55,200xg and capacity of 6L for bottles, tubes, or microplates. Patented features such as the Automatic Rotor Identification and Rotor Cover Detector make the CR22N the ideal separation tool for multiple research applications involving DNA, RNA, viruses, proteins, and more

Used Arrow Lab Mixer Used Arrow Lab Mixer

Used Arrow air drive lab size mixer with shaft and prop.

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