The Versatility Of Charged Aerosol Detection
Charged Aerosol Detection (CAD) applies to a broad range of HPLC separations and possesses a number of desirable characteristics for detection and quantitation of various compounds including those without UV absorbing chromophores.
WHITE PAPERS & CASE STUDIES
Simplify Analysis Of Low Density Pharmaceutical Samples
A major advantage for using the TriStar II with the Krypton Option is the ability to measure low surface areas. Although the TriStar II standard nitrogen system can measure surface areas as low as 0.01 m2/g, the Krypton Option enables you to measure areas as low as 0.001 m2/g and provides increased accuracy for materials under 1.0 m2/g. Krypton is also useful for analyzing materials that are difficult to sample or have very low density; pharmaceutical lubricants, for example.
Solution For Difficult-to-Measure Pharmaceutical Binders
Krypton is an excellent choice for low surface area measurements. At 77 K, nitrogen has a saturation pressure of 760 torr, whereas krypton has a saturation pressure of only 2.5 torr.
Detection of Microbial Contamination in Sterile Containers using Headspace Analysis
Sterility testing in the pharmaceutical industry has long been based on growth media culture methods. The general approach is to incubate for 14 days and then determine potential contamination with a visual inspection of the media sample
Container Closure Integrity of Sterile Vials During Deep Cold Storage
Certain sterile pharmaceutical products require deep cold storage, either at dry ice (-80°C) or even cryogenic (−196 °C) temperatures.
Nitrogen Purge Optimization and Validation of Sterile Liquid Filling Lines
Sterile liquid filling lines are increasingly being implemented with nitrogen purge capability during filling.
Container Closure Integrity Testing in Lieu of Sterility Testing in Stability Protocols
When the Food and Drug Administration published “Guidance for Industry: Container and Closure System Integrity in Lieu of Sterility Testing as a Component of the Stability Protocol for Sterile Products”