Comparative Evaluation Of Automated Flash Chromatography And Preparative HPLC For Bench-Scale Purification Of A Broad Range Of Sample Types
The goal of a purification chemist is to deliver suitable quantities of high purity compounds in the shortest possible time. Two of the most popular purification techniques are Automated Flash Column Chromatography (AFCC) and Preparative HPLC. Traditionally, AFCC is characterized by the ability to load large amounts of material and has short purification times, while Prep HPLC is valued for high resolution separations resulting in very pure products. As a result, AFCC is often used as a preliminary technique whereby the crude sample is pre-purified before final high resolution purification using Prep HPLC. By Bopanna N.K., Chitra Sundararajan, and Mark Jacyno
WHITE PAPERS & CASE STUDIES
Modular Facility Design: A Cost-Effective Option In The Post-Blockbuster Drug Era
The pharmaceutical industry has undergone a sea of change in recent years as manufacturers have adapted to the end of the era of large-volume production of mass-market blockbuster drugs. With firms now focusing in on subpopulations of patients, there is a need for lean, adaptable facilities that can switch quickly between multiple products in multiple formats. Modular facilities can meet this need. While not a panacea, for the right project characteristics, ‘Modularity in Design’ can deliver significant and quantifiable long-term value.
How To Increase Regulatory Flexibility And Tablet Production Efficiency
The goal of every pharmaceutical developer is to create quality products which generate consumer satisfaction, require low cost, and have low risk. Quality starts from the moment of conception of an idea and continues throughout production.
The Effect Of Tablet Porosity On Dissolution
Porosity is a characteristic that influences many of the critical quality attributes of finished pharmaceutical products. Porosity can help predict deformation properties during compression, pharmacokinetic behavior within the body, shelf life, moisture penetration, and bioavailability.
Excipients: The Unsung Heroes Of Pharmaceuticals
<p>Excipients are often described as inactive ingredients that assist in the delivery and processing of the active pharmaceutical ingredients. Although this is true, excipients have a much larger influence on final product performance than the term “inactive ingredient” suggests. In fact, choosing the right excipients is a key determinant of the quality and functionality of a pharmaceutical product.</p>
Fundamentals Of Spray-Dried Dispersion Technology
A common problem statement in the pharmaceutical industry is low oral bioavailability of drug candidates with poor aqueous solubility. The literature suggests that a significant majority of new drug candidates are in the Biopharmaceutics Classification System (BCS) class II and IV space, which includes compounds that are dissolution rate, solubility or permeability limited to absorption, or all three. As portfolios across the industry are increasingly focused on these compounds, the need for enabling technologies continues to grow.
The Importance Of Steel Quality In Tablet Compression Tooling
Steel quality is the summation of how well a steel meets its specified chemistry, the cleanliness of the steel or degree to which it is free of impurities or inclusion, homogeneity of the microstructure, grain/carbide size and in some instances if it meets the mechanical requirements for that particular steel.