The Steam-Thru Connections' three-port design allows steam to pass directly through the two lower ports. After the "steam on" SIP cycle is completed, the connector's valve is actuated, creating a sterile flow path. Media can now be safely transferred between a bioreactor and single- use system without the cleaning and validation concerns associated with reusable components.

Steam-Thru II offers the flexibility and reliability of "steam on" and "steam off" functionality. Following media transfer, the valve can be moved to the steam position. A second SIP cycle further minimizes contamination risks by allowing a sterile disconnection.

Steam-Thru Connections help today's biopharmaceutical manufacturers meet the challenges of increasing productivity, reducing costs, and decreasing time to market.

100% committed to the Patheon Customer Experience — that's our guarantee.

DSM Pharmaceuticals, Inc., a business unit of DSM Pharmaceutical Products, is an established custom manufacturer providing clinical trial custom manufacturing services to the biopharmaceutical and pharmaceutical industries worldwide.

CTM services from DSM include:

Vetter is an independent, international specialist in the production of aseptically prefilled injection systems, cartridges, and vials. For more than 25 years, the name of Vetter has stood for quality, innovation, and strategic partnerships. Our customized products and processes have been approved by the FDA, the EMEA, and other authorities, which ensures a maximum of quality and safety. Our customers from the biotech industry can count on highly efficient collaboration and strict adherence to international standards. This particularly means best support for perfect adaptation of administration of the active ingredient. Our production processes are both as effective and as cautious as possible with the active ingredients. Combined with our innovative application systems they come up to the high expectations of these types of sensitive substances. From the development phase through to global market supply, Vetter thus helps its partners' products to advance in their markets.

The Prevas™ Disposable Dosing System is the latest technology from Bosch Packaging Technology's Pharma business unit. Prevas is the industry's first prevalidated, preassembled, and presterilized liquid dosing system for clinical and production applications. Prevas is available in a number of standard or custom configurations. Disposable dosing systems eliminate costly cleaning and validation procedures, making them an economical and easy-touse solution.

• USP/NF Class IV Materials
• Gamma Irradiated
• Preassembled, Ready to Use
• ISO 11137 Sterilization
• No Cleaning or Validation
• Economical
• Reduced Operator Exposure

K-Tron Process Group manufactures solids and liquid feeders, pneumatic conveying equipment, and systems specific to the pharmaceutical industry.

The K-Tron Micro-Ingredient (MT12) feeder and other pharmaceutical feeders are available in twin-screw, volumetric, and loss-in-weight versions. Applications include jet milling, extrusion, dispensing, continuous blending, granulation, coating, and lubricant feeding. Premier Pneumatics conveying equipment meets demanding requirements of powder transfer for dilute and dense phase applications. K-Tron has engineered process automation systems including:

• Extrusion — both wet granulation and hot melt types
• Lubrication of tablet press tooling
• Continuous direct compression, blending, and coating systems
• Feeding for milling and micronization of powders
• Dispensing applications

K-Tron's designs are engineered to meet rigid requirements of cGMP standards and the use of FDA approved/certified materials of construction. All units are designed for cleaning requirements, ease of disassembly and maintenance, and required containment levels.

Options include systems integration for batch or continuous processing, containment designs, and CIP rinse in place designs.

Thermo Scientific Darwin LIMS™ is specifically designed to address the unique needs of pharmaceutical manufacturing and research and development QA/QC labs. Darwin's unique batch and product-oriented design aligns directly with pharmaceutical manufacturing processes, allowing research and development and production data to be logically organized, summarized, and reported. The substantial costs and risks associated with customizing a generic laboratory information management system (LIMS) to serve the needs of pharmaceutical manufacturing have given rise to the trend toward out-of-the-box, or purpose-built, software solutions like Darwin.

The benefits of application-specific LIMS are obvious: less customization means dramatically reduced implementation, training, validation, and maintenance costs — for a lower total cost of ownership and higher end-user acceptance.

Anteco Pharma offers formulation, lyophilization, and packaging services to the pharmaceutical, medical device, and food industries. We specialize in innovation, flexibility, and quick response with a new GMP compliant facility, state-of-the-art equipment, and an experienced staff with track records of success.

Services include:

• Lyophilization capacity from 1 liter to 2000 liters
• Class 10,000 manufacturing suites
• Temperature-controlled processing and storage
• Formulation
• Packaging
• Process development, scale-up, and process transfer
• Project management and compliance support

Our quality system is compliant with drug, medical device, and food GMPs. Customer and third-party audits are encouraged and supported.

Let us show you how we can use these resources to provide cost-effective solutions to your toughest manufacturing challenges.

Foster Pharma is a polymeric materials and process specialist on a mission to provide innovative solutions to current and future drug delivery challenges. These polymeric materials are modified to include a functional active or pharmaceutical ingredient to increase solubility and bioavailability, achieving greater therapeutic results.

Foster's melt technology increases the safety and security of innovative therapies and improves the overall performance of the drug. Foster's technology can be applied to applications such as controlled release of drugs, bioresorbable coatings for medical devices, taste-masking, targeted delivery, patient-specific solutions, adulteration-proofing, ingestible substrates, drug capsules, antimicrobial products, anti-counterfeiting measures, and other technologies. With a focus on cost-effectiveness, the melt extrusion process is well-suited for generics, low-volume, and orphan drug formulations. Activities include engineering planning, design, experimenting, development, formulation development support, process trials, scale-up, manufacture of supplies for bioavailability and clinical trials, validation, technology transfer, and production.

The GORE™ STA-PURE^SM Bioprocess Configurator for Custom Assembly Design enables customers to minimize fluid assembly system design time while providing fully customizable design options specific to various process needs.

GORE™ LYOGUARD® Freeze-Drying Products improve lyophilization processes while reducing product and freeze-dryer contamination risk.

GORE® Filtration Products help to optimize product collection of pharmaceutical dry powders as well as dust emissions.

GORE™ Microfiltration Media enables pharmaceutical filter manufacturers to engineer high-performing, reliable filters.

GORE™ Packaging Vents facilitate closed, pressure-equalized systems for multi-dose drug packaging applications.

R.W. HARTNETT COMPANY
Women Owned #7098058GC

Founded in 1880, R.W. Hartnett Co. is the original designer and first manufacturer of tablet, hard gelatin capsule, and soft gelatin printing machines. Both large pharmaceutical and small entrepreneurial companies continue to rely upon our pioneering approach for their technological and mechanical solutions. R.W. Hartnett Co. is recognized around the world for producing a superior, dependable product. R.W. Hartnett Co. currenty has machines in more than 33 countries. All our machines are customized specifically for your product. Ink printing and laser printing (non-contact) are just two of the operations of our machines. Custom inspection/rejection systems can be added to any of our machines to ensure a perfect print — each and every unit printed. No matter the size, shape, or texture of your product, we can print it. We proudly mark this, our 128th year in business.