INSIGHTS ON SOLID DOSE MANUFACTURING

SOLID DOSE MANUFACTURING SOLUTIONS

  • Our rotary turret uses proven tablet-press -based, principles. It progressively compresses powder into small pockets on a continuously rotating disk using a combination of rotors and pins. The resultant doses are then transferred to blister strip as it passes underneath the disk.

  • Used ACG capsule filler, model AF TLab, speeds from 6000-25000 capsules/hour, 220 volt, CE design, batch# 2522/10/01, serial# 102, built 2020. includes ACG capsule polisher unit, model DP100, batch# DP62/30/21, serial# 2664, built 2020 and ACG empty capsule sorter, model ECS 100, batch# EC60/30/03, serial# 2098, built 2020.

  • Basic Powder Flow Characterization [USP <1174>]:

    A powder flow analysis is an indicator of how well formulation will release from the hopper during the tableting. It is important to know that the developed formulation is showing ‘Mass Flow’ or ‘Funnel Flow’ or ‘Rat Holing’.

    Powder blend shows ‘Mass Flow’ when the entire solid bed is in motion during the discharge of material from the outlet. This is a ‘First-in-First-Out’ process. Hoppers offering ‘Mass Flow’ have steep and/or low-friction walls. This flow offers ‘No-Arching’, ‘Less Segregation’, and ‘Stable Powder Flow’.

    When the hopper is not sufficiently steep and smooth enough to ensure sliding along its wall, the powder blend exhibit ‘Funnel Flow’. Such hoppers are sensitive to arching and ratholing. In this case, powder discharge from the hopper is not predictable.

  • An oral solid pilot plant paired with pharmaceutical technology and analytical development labs, built inside a commercial production campus, supports work through clinical batches and small-scale commercial supply.

  • Personal protection pharmaceutical isolators enables personal protection for operators when handling toxic substances.