INSIGHTS ON SOLID DOSE MANUFACTURING
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Safely Scaling High Potency API Manufacturing
Scaling HPAPI production demands disciplined containment and exposure control. Integrated operating models help manage risk while enabling compliant, reliable scale‑up.
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Predicting Drug-Loading Limits In Tablet Formulations
Learn how predictive percolation modeling identified critical drug-loading limits of ~20% for crystalline API and ~15% for SDD forms, cutting tablet formulation trial-and-error significantly.
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How High Drug Load Nanocrystalline Tablets Lower Pill Burden
We showcase the development of high drug load nanocrystal based tablets and prove that nanocrystals can match the pharmacokinetic performance of ASDs while reducing the overall pill burden.
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Fundamentals Of Power Blending Simulations
Predicting blending quality doesn't have to be a guessing game. Learn how to leverage virtual prototypes to make informed decisions and minimize costly trial-and-error in tablet manufacturing.
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GLP-1 Oral Solid Dosage Workflow - Spray Drying And Tableting6/29/2026
Optimize containment in oral GLP-1 solid dose manufacturing. Learn how closed single-use containment and flexible isolators secure blending, spray drying, and tableting workflows.
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Ask Us Anything: Daniele Vigo On Cost-Effective Process Development7/23/2026
Daniele Vigo, Assistant Director at Cambrex Milan, on getting yield, purity, and scalability right without burning through the budget.
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An Alternative Method Of Drug-Excipient Characterization12/30/2024
Isothermal microcalorimetry (IMC) rapidly screens API-excipient compatibility, detecting physical and chemical interactions faster than conventional methods, saving time and effort in pharmaceutical formulation development.
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Patient Adherence With A Novel Dosage Form11/13/2025
A sprinkle formulation helps patients with tremors or dysphagia take medication more easily, improving adherence, comfort, and care through a novel, FDA-approved oral granule format.
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Converting From A Spray-Dried Dispersion To A KinetiSol Formulation In <5 Months2/26/2026
A development team quickly turned a low‑bioavailability, high‑burden formulation into a streamlined, clinically improved version, boosting exposure, simplifying manufacturing, and accelerating progress.
SOLID DOSE MANUFACTURING SOLUTIONS
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With ample available capacity, Ropack Pharma Solutions provides the efficiency of five bottling lines with quick changeovers, online validated fill accuracy and the flexibility to accommodate small lots to commercial runs for the bottling of tablets, capsules and powders.
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Handling today’s higher-potency active pharmaceutical ingredients (HPAPIs) presents ever-increasing regulatory concerns — especially within manufacturing-area isolators and lab areas, and for flexible GMP chambers where airflow, temperature, humidity and pressure differentials exist from room to room.
The JetVent™ system’s precise fan speed delivers accurately controlled negative air pressure to ensure proper flow into flexible-wall isolators, while reducing the risk of worker exposure.
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Active pharmaceutical ingredient (API) manufacturing requires powder handling in a GMP and contained manner. Similar to chemical manufacturing, operations like charging powders into a chemical reactor, emptying a centrifuge or charging and discharging a dryer are standard processes.
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Stop wasting time on frustrating, trial-and-error methods to level your tablet press feeder platform. "Close enough" isn't good enough—especially when it leads to excess formulation loss or costly equipment damage. With the Natoli EZ Level™ Feeder Base Leveling System, you can achieve fast, accurate, and repeatable results—every time.
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Enhance dissolution and lubrication in solid oral formulations. See how this approach supports poorly soluble actives, modern manufacturing methods, and consistent performance.