INSIGHTS ON SOLID DOSE MANUFACTURING
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Taste-Masked Dosage Forms For Pediatric Oral Delivery: An Industrial Perspective
Leveraging strategies and technologies for pediatric patient compliance for taste masking and controlled release in pharmaceutical products, enables flexibility in dosage and format options.
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The Future Of Pharma Packaging Trends, Technologies, And Patient-Centric Solutions
Pharmaceutical packaging must evolve alongside drug development to ensure stability, safety, and regulatory adherence, utilizing innovative designs to improve therapeutic outcomes and patient accessibility.
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Blending And Simulation: A Beginner's Guide
This beginner-friendly webinar reveals essential steps to understand mixing, reduce segregation, enhance efficiency, and improve product quality with granular materials.
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Tablets And Capsules: Overcoming Similar Obstacles In Production
Explore how understanding specific USP chapters can address common tablet and capsule production challenges and ensure high-quality results in this essential pharmaceutical process.
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Smart Softgels: Driving Innovation In Pharma7/29/2024
Learn about how softgels are poised to facilitate innovation in the pharmaceutical industry as well as ongoing advancements in optimizing drug bioavailability through nano formulations.
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Spray Dry Biologics For Oral Dosage Forms5/15/2026
Spray drying enables stable oral delivery of biologics by creating protective dry powders, improving bioavailability, stability, and targeted release compared with traditional formulation methods.
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Lower Punch Tip Bending / Buckling11/11/2024
When manufacturing mini-tablets, adjusting punch force ratings is crucial to prevent bending or buckling. The Rankine-Gordon formula offers a safer force rating for microtip tooling.
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Cytiva's Aseptic Filling Workcell User Group1/9/2026
Discover how global collaboration among aseptic filling experts is driving innovation and improving operations.
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Blister Solutions3/4/2025
With over 6,000 tooling parts and an in-house machining center to ensure precision, explore this versatile blister service that provides both Thermoformed and Cold-Formed solutions.
SOLID DOSE MANUFACTURING SOLUTIONS
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Setting a New Benchmark for Ease of Operation
The NP-255 is a robust tablet press that was built to meet even the most demanding needs of the mid-sized tableting industry. The press has features and options designed to increase production, improve tablet quality, reduce waste, and set a new benchmark for ease of operation. Designed, engineered, and manufactured in the USA, this unique machine has a maximum production speed of 192,000 tablets per hour.
With a hardened steel die table, a gravity feeder that is interchangeable with a two-paddle forced feeder, and our industry-leading intuitive Natoli AIM™ ProPluscontrol system, the NP-255 is the new standard for value in the mid-sized tableting industry.
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Used Syntegon high speed capsule filler, model KKE 1700, speeds up to 103,200 capsules/hour, 758541, built 2022.
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Basic Powder Flow Characterization [USP <1174>]:
A powder flow analysis is an indicator of how well formulation will release from the hopper during the tableting. It is important to know that the developed formulation is showing ‘Mass Flow’ or ‘Funnel Flow’ or ‘Rat Holing’.
Powder blend shows ‘Mass Flow’ when the entire solid bed is in motion during the discharge of material from the outlet. This is a ‘First-in-First-Out’ process. Hoppers offering ‘Mass Flow’ have steep and/or low-friction walls. This flow offers ‘No-Arching’, ‘Less Segregation’, and ‘Stable Powder Flow’.
When the hopper is not sufficiently steep and smooth enough to ensure sliding along its wall, the powder blend exhibit ‘Funnel Flow’. Such hoppers are sensitive to arching and ratholing. In this case, powder discharge from the hopper is not predictable.
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Used IMA Zanasi 6 F Capsule Filler, rated up to 6000 capsules/hour, no change parts, capable of producing 00-5 size capsules, with controls and Siemens PLC, 230 volt, 3 phase, serial# 35071, built 2006.
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Used Sensum tablet inspection machine, model SPINE, designed for inspection of complete surface of tablets, including engraving, speeds up to 360,000 tablets/hour for round and oblong plain tablets, 240,000/hour for engraved round tablets, 300,000 tablets/hour for oblong engraved tablets, with stainless steel product hopper and integrated operator HMI, 230 volt, 60 hertz, CE design, serial# 073, built 2017.