INSIGHTS ON SOLID DOSE MANUFACTURING
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![Natoli - blending guide webinar]( "Blending And Simulation: A Beginner's Guide")
Blending And Simulation: A Beginner's GuideThis beginner-friendly webinar reveals essential steps to understand mixing, reduce segregation, enhance efficiency, and improve product quality with granular materials.
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![Cytiva's Aseptic Filling Workcell User Group]( "Cytiva's Aseptic Filling Workcell User Group")
Cytiva's Aseptic Filling Workcell User GroupDiscover how global collaboration among aseptic filling experts is driving innovation and improving operations.
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![GettyImages-923626190-magnifying-glass-pill-tablets-powder]( "Low-Bioburden Powders For Terminal Sterilisation")
Low-Bioburden Powders For Terminal SterilisationLow‑bioburden powders for reconstitution demand strict microbial control, advanced formulation, and specialised manufacturing, making CDMO expertise vital for modern biopharma.
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![GettyImages-2190175396 osd, tablets, manufacturing]( "5 Advancements In Tablet Compression That Pharma Can't Ignore In 2026")
5 Advancements In Tablet Compression That Pharma Can't Ignore In 2026New materials, smart automation, and in-press quality control are optimizing tablet compression. These five key innovations are driving efficiency and consistency in solid dose manufacturing today.
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Blister Solutions3/4/2025
With over 6,000 tooling parts and an in-house machining center to ensure precision, explore this versatile blister service that provides both Thermoformed and Cold-Formed solutions.
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6 Strategic Pillars For Selecting A Drug Packaging Partner4/14/2026
Early engagement with an expert packaging partner supports safe, cost-effective drug development and logistical success from precommercial stages through full market launch.
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Enabling Complex Phase IIa Dosing Through Flexible Clinical Packaging Design5/6/2026
Discover how flexible, patient‑centric clinical packaging supports complex Phase IIa dosing while protecting timelines, ensuring compliance, and avoiding costly primary packaging changes.
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The Role Of Quality By Design In Pharmaceutical Tablet Development7/30/2024
Quality by Design (QbD) ensures efficiency and high standards in pharmaceutical tablet development. Explore how this proactive approach transforms manufacturing processes and enhances product quality.
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Accelerating An Innovative High Potency Oncology Therapy To Market5/13/2026
Learn how disciplined containment, proactive risk management, and collaboration accelerate complex oncology programs under tight timelines while protecting quality, safety, and global launch readiness.
SOLID DOSE MANUFACTURING SOLUTIONS
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![GettyImages-669121480-pill-tablet-capsule-OSD-oral-solid]( "Oral Solid Dose Formulation Assessment Services")
Send a test sample of your powder to Natoli Scientific to get your formula characterized following USP <1062> Guidelines (Tablet Characterization Methods) that we have been practicing for over 25 years.
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![GettyImages-1311641109-capsule-tablet-pill-OSD-oral-solid]( "Oral Solid Dose Formulation And Lab Scale Capabilities")
Natoli Scientific is dedicated to developing high-quality affordable products for your market needs.
We provide a formulation design based on a strong scientific understanding and decoding interplay of materials and process parameters to ensure product integrity. We use traditional as well as principles of ‘Quality by Design (QbD)’ to develop robust lead prototype formulations. The early sound scientific investment in product development saves time and money during scale-up and commercial manufacturing.
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![iStock-870087778-powder]( "Powder Flow Properties & Characterization Services")
Basic Powder Flow Characterization [USP <1174>]:
A powder flow analysis is an indicator of how well formulation will release from the hopper during the tableting. It is important to know that the developed formulation is showing ‘Mass Flow’ or ‘Funnel Flow’ or ‘Rat Holing’.
Powder blend shows ‘Mass Flow’ when the entire solid bed is in motion during the discharge of material from the outlet. This is a ‘First-in-First-Out’ process. Hoppers offering ‘Mass Flow’ have steep and/or low-friction walls. This flow offers ‘No-Arching’, ‘Less Segregation’, and ‘Stable Powder Flow’.
When the hopper is not sufficiently steep and smooth enough to ensure sliding along its wall, the powder blend exhibit ‘Funnel Flow’. Such hoppers are sensitive to arching and ratholing. In this case, powder discharge from the hopper is not predictable.
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Data acquisition and analytical and operating system software for tablet press R&D, production, and more.
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![Getty Images-823447656-vector-viral-lab-AAV-cell-development]( "Global Experts In Nanotechnology And Drug Particle Engineering")
Discover the nanoparticle engineering, formulation and GMP manufacturing services that can drive forward your market success and unlock the power of “small."
