INSIGHTS ON SOLID DOSE MANUFACTURING
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Optimizing DPI Production: Filling Technologies For Precision And Performance
Developing effective dry powder inhalers requires expertise across multiple disciplines, from particle engineering and device technology to manufacturing science and regulatory knowledge.
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Harnessing Digital Twins To Optimize Tablet Manufacturing
Unlock manufacturing precision with digital twins. Learn how virtual replicas of production systems enable predictive maintenance, streamline scale-up, and ensure consistent product quality in pharma.
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A Powerful Non-Destructive Tool For Tablet Characterization
Discover how X-ray micro-CT provides vital, non-destructive analysis of a tablet’s internal 3D physical structure. This structural insight is essential for troubleshooting defects and confirming performance.
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Patient Adherence with A Novel Dosage Form
A sprinkle formulation helps patients with tremors or dysphagia take medication more easily, improving adherence, comfort, and care through a novel, FDA-approved oral granule format.
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Fundamentals Of Power Blending Simulations2/26/2025
Predicting blending quality doesn't have to be a guessing game. Learn how to leverage virtual prototypes to make informed decisions and minimize costly trial-and-error in tablet manufacturing.
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Layer By Layer: 3D Screen Printing And The Future Of Drug Development8/15/2025
3D screen printing can produce tablets across a range of release profiles, from conventional immediate release tablets to multi-compartment drug delivery systems that mix different release profiles.
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Engineering Challenges Of Designing Pharmaceutical Isolators3/27/2025
Designing pharmaceutical isolators requires navigating complex engineering hurdles, from ensuring chemical compatibility to optimizing airflow and pressure. Explore the critical considerations that guarantee drug manufacturing safety and efficiency.
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Closing The Duration Gap In FDA-Approved Long-Acting Contraceptives7/17/2024
A gap exists between three months and three years in FDA-approved long-acting contraceptives (LACs). A microsphere formulation enables sustained release over a six to twelve-month period.
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Future Of Pharma Packaging: Trends, Tech, And Patient Solutions9/25/2025
Explore how traditional and innovative pharmaceutical packaging formats improve patient adherence, support emerging therapies, and shape the future of drug delivery and treatment outcomes.
SOLID DOSE MANUFACTURING SOLUTIONS
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The Quadro Comil / High Shear Diosna Milling and Granulation Enclosure designed to provide personnel protection down to a respiratory exposure concentration of 100 nanograms per cubic meter (ng/m3) during milling and granulation operations.
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Contract Development and Manufacturing Organizations (CDMOs) provide a comprehensive, single-source drug development and commercial manufacturing solution that requires unyielding safety and processing standards. We believe that understanding the importance of our client’s process first is the key to a successful partnership.
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Partner with Natoli Scientific during the earliest stages. Our scientific expertise with state-of-the-art analytical capabilities is ready to take any preformulation challenge.
Natoli scientific has an expertise of handling a wide range of APIs for the development of oral solids. We apply principles of ‘Quality by Design’ to define Critical Material Attributes (CMA), Critical Process Parameters (CPP), Critical Quality Attributes (CQA) and Quality Target Product Profiles (QTPP). Because we believe that understanding material and process as much as possible in the early life cycle of drug product development program is an insurance for further development path. Keeping your practices up to date with the ICHQ8 regulatory guidance issued by the US FDA. This is also a gate way for a smooth ride of product in the different stages of product development stages.
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Used Kilian rotary tablet press, model T100, 16 station, B/D IPT turret, with (8) B tooled, 16 mm diameter, 16 mm depth of fill and (8) D tooled, 25 mm diameter, 16 mm depth of fill stations in single turret, with additional 9 station IPT B toolded turrent, 42 Kn pre-compression, 65 Kn main compression, keyed upper punch guides, singled sided with force feeder, commission# 706849, built 2002.
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At Natoli, we know that quality is paramount. Our cutting‐edge Precision CT Scan Service is designed to detect even the subtlest imperfections in tablets, ensuring you achieve the highest standards of quality every time.