INSIGHTS ON SOLID DOSE MANUFACTURING

  • Lower Punch Tip Bending / Buckling

    When manufacturing mini-tablets, adjusting punch force ratings is crucial to prevent bending or buckling. The Rankine-Gordon formula offers a safer force rating for microtip tooling.

  • Integration From Formulation Development To Manufacturing, Packaging

    Adare Pharma Solutions' Pessano, Italy facility offers 220,000 sq. ft. of end-to-end services, including R&D, formulation development, clinical and commercial manufacturing, packaging, and advanced analytical capabilities.

  • Future-Proofing Aseptic Manufacturing

    Investing in adaptable aseptic manufacturing pays off. Find out how flexible systems, despite higher initial costs, handle complex drugs and changing volumes to boost productivity and quality.

  • Benefits Of Isolator Technology In Fill-Finish

    Isolator technology enhances sterility assurance, reduces contamination risk, improves operator safety, and supports regulatory compliance, making it essential for modern aseptic fill-finish operations.

SOLID DOSE MANUFACTURING SOLUTIONS

  • Used ACG Pam Mini Filled Capsule Sorter, model MCS100, stainless steel construction, 9" x 12" sorting area, serial# MCS-559.

  • Used Shionogi Qualicaps quali-fill capsule filling machine, serial# 96-F40.

  • Basic Powder Flow Characterization [USP <1174>]:

    A powder flow analysis is an indicator of how well formulation will release from the hopper during the tableting. It is important to know that the developed formulation is showing ‘Mass Flow’ or ‘Funnel Flow’ or ‘Rat Holing’.

    Powder blend shows ‘Mass Flow’ when the entire solid bed is in motion during the discharge of material from the outlet. This is a ‘First-in-First-Out’ process. Hoppers offering ‘Mass Flow’ have steep and/or low-friction walls. This flow offers ‘No-Arching’, ‘Less Segregation’, and ‘Stable Powder Flow’.

    When the hopper is not sufficiently steep and smooth enough to ensure sliding along its wall, the powder blend exhibit ‘Funnel Flow’. Such hoppers are sensitive to arching and ratholing. In this case, powder discharge from the hopper is not predictable.

  • Used Syntegon high speed capsule filler, model KKE 1700, speeds up to 103,200 capsules/hour, 758541, built 2022.

  • Sterility testing isolators with product protection for the sterility test under aseptic and optionally aseptic/toxic conditions. A Rapid Decon Hatch (RDH) can be connected as an option.