INSIGHTS ON SOLID DOSE MANUFACTURING

SOLID DOSE MANUFACTURING SOLUTIONS

  • Multiparticulates enable tailored drug release with improved flexibility, dose accuracy, and patient convenience, leveraging technologies like Diffucaps® for customized profiles including immediate, delayed, extended, and pulsatile delivery.

  • Used 60" O'Hara FastCoat coating pan, model FC400 (60xc5), stainless steel construction with 60" diameter perforated Pan, solvent rated design, O'Hara advanced controls with Allen Bradley Compact Logix PLC, PC and HMI units, O'Hara manifold with Schlick nozzle spray arm, built in Watson Marlow peristaltic pump with Micromotion mass flow and recirculation system, reverse pan unloading, outdoor rated air handling unit (AHU) with preheat steam coil, chilled water dehumidification unit, steam reheat with face/bypass temp control dampers, HEPA module, Camfil DCU with FIKE suppression and isolation system, bag in bag out with exhaust HEPF module, 480 volt, system serial# 4501, built 2020.

  • Personal protection pharmaceutical isolators enables personal protection for operators when handling toxic substances.

  • When AST came to the table on the design for our new fill-finish isolator, one of the first areas AST engineers wanted to address was the usability and accessibility of the isolator and corresponding operations. With our customers’ point of view in mind, we wanted to address specific points of friction routinely encountered by operators and closely examine whether those friction points were necessary.

    Does an isolator need to be ergonomically unfriendly to clean?

    Should simple mechanisms like isolator doors be challenging to engage? (As much as one can appreciate exercise, no one wants to do “arm day” in cleanroom coveralls).

    Does routine maintenance have to be time-consuming and laborious?

    Many of these factors are accepted as par for the course in aseptic fill-finish manufacturing. Our question was, why?

  • Natoli Engineering now offers AIM™ Data Acquisition & Analytical Software for the Natoli NP-RD10A research and development tablet press. The combination of AIM™ Software and this R&D tablet press enables the researcher to evaluate formulation properties and identify potential tableting issues—including capping, lamination, sticking/picking, and tablet robustness—during the tablet development process. Plus, the software can optimize tablet tensile strength and lubrication for successful large-scale manufacturing production.