INSIGHTS ON SOLID DOSE MANUFACTURING
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![GettyImages-1381220899 tablets, pills, OSD, small molecule]( "GLP-1 OSD Chemical Synthesis Workflow")
GLP-1 OSD Chemical Synthesis WorkflowEnhance containment and process reliability in oral GLP-1 synthesis. Discover how integrated single-use assemblies and automated fluidics safeguard chemical purity during scale-up.
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![Ecolab - isolator]( "Isolators For Pharmacy Compounding – Time For Change?")
Isolators For Pharmacy Compounding – Time For Change?Maintaining a contamination-free environment is crucial in drug compounding. Learn how isolator systems can improve safety, efficiency, and regulatory compliance.
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![Nurse, patient, and daughter talking about prescription medication in a hospital-GettyImages-2210890101]( "How Dosage Form Decisions Shape Pediatric And Geriatric Drug Development")
How Dosage Form Decisions Shape Pediatric And Geriatric Drug DevelopmentDeveloping pediatric and geriatric pharmaceuticals requires customized strategies beyond tablet crushing, balancing specific age-related palatability, packaging, real-world administration, and lifecycle management needs for optimal patient outcomes.
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![GettyImages-1499814881-pills-production-line]( "Converting From A Spray-Dried Dispersion To A KinetiSol Formulation In <5 Months")
Converting From A Spray-Dried Dispersion To A KinetiSol Formulation In <5 MonthsA development team quickly turned a low‑bioavailability, high‑burden formulation into a streamlined, clinically improved version, boosting exposure, simplifying manufacturing, and accelerating progress.
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Predicting Food Effects In Oral Drug Delivery Using PBPK Modeling7/15/2026
Learn how integrated PBPK and molecular dynamics modeling predicted an ~11% fed-state Cmax increase for fenofibrate, giving formulation teams earlier, mechanistic insight into food-dependent absorption.
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Overload Setting – Tricks And Techniques9/23/2024
Learn how a partner company that is committed to assisting manufacturers with calibration and optimal set-point establishment can serve as a valuable resource in achieving optimal tablet production.
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Oral Delivery Of PROTACs: Integrating Molecular Design And Enabling Formulation8/20/2026
Explore how integrated molecular design and formulation strategies can overcome the unique oral-delivery challenges of PROTACs, transforming complex degraders into viable, scalable medicines.
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Lower Punch Tip Bending / Buckling11/11/2024
When manufacturing mini-tablets, adjusting punch force ratings is crucial to prevent bending or buckling. The Rankine-Gordon formula offers a safer force rating for microtip tooling.
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The Importance Of Tablet Density Uniformity10/7/2025
Non-uniform density causes many tablet failures. Learn how optimizing your formulation, tablet proportions, and tooling design ensures proper de-aeration for consistent quality.
SOLID DOSE MANUFACTURING SOLUTIONS
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![4326-1-01]( "Used Marchesini Sachet Filler, Model MS235")
Used Marchesini Sachet Filler, model MS235, speeds up to 500 sachets/ min, at up to 75 cycles/minute, 60mm - 150 mm long x 25mm wide package size range, packages individually or in pair with a tear line in between, inline automatic process weight verification with auto-correction of the fill target, explosion-proof, individual coded sachets, currently set up as 8 lane with integrated 8 lane pick and place stacker, serial# M2160002, built 2017.
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![Intermittent Forming, Filling And Sealing Of Blisters for Inhalation ProductsMSP pic 1]( "Intermittent Forming, Filling And Sealing Of Blisters for Inhalation Products")
Achieve commercial-scale inhalation blister manufacturing with outputs up to 2,400 cavities per minute, flexible powder dosing, and integrated containment options.
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![3P Innovation - compression blister filler]( "Compression Blister Filler System")
Forming part of 3P innovation’s Discover Range, this early-stage development unit uses two sets of die punches to compress pellets and seal them within a blister strip. Used predominantly for dry powder inhalers (DPIs), the ultra-compact filler fits on your lab benchtop.
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![Esco- Containment Barrier Isolator )CBI) unidirectional]( "Containment Barrier Isolator (CBI): Your Practical Solution To cGMP Compliance")
Maintain peak safety and sterility in sensitive environments with advanced isolation technology. Ensure strict compliance and reliable protection during critical, high-stakes processing tasks.
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![iStock-1191001266-tablet-pill]( "Oral Solid Dose Formulation Troubleshooting Support Services")
Natoli organization is a reputed leader with more than a half century experience in the tablet manufacturing technology.
We understand tablets better. We are here for serving your needs to overcome challenges associated with commercial manufacturing of solid dosage forms across the globe (North America, Europe, Asia).
Our Natoli scientific team uses holistic approach to understand and solve important tableting problems like capping, lamination, picking, and sticking. We integrate scientific information gathered at material, process, and instrument level to understanding and decode root causes of these common tableting issues.
