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INSIGHTS ON SOLID DOSE MANUFACTURING

SOLID DOSE MANUFACTURING SOLUTIONS

  • The Quadro Comil / High Shear Diosna Milling and Granulation Enclosure designed to provide personnel protection down to a respiratory exposure concentration of 100 nanograms per cubic meter (ng/m3) during milling and granulation operations.

  • Contract Development and Manufacturing Organizations (CDMOs) provide a comprehensive, single-source drug development and commercial manufacturing solution that requires unyielding safety and processing standards. We believe that understanding the importance of our client’s process first is the key to a successful partnership.

  • Partner with Natoli Scientific during the earliest stages. Our scientific expertise with state-of-the-art analytical capabilities is ready to take any preformulation challenge.

    Natoli scientific has an expertise of handling a wide range of APIs for the development of oral solids. We apply principles of ‘Quality by Design’ to define Critical Material Attributes (CMA), Critical Process Parameters (CPP), Critical Quality Attributes (CQA) and Quality Target Product Profiles (QTPP). Because we believe that understanding material and process as much as possible in the early life cycle of drug product development program is an insurance for further development path. Keeping your practices up to date with the ICHQ8 regulatory guidance issued by the US FDA. This is also a gate way for a smooth ride of product in the different stages of product development stages.

  • Used Kilian rotary tablet press, model T100, 16 station, B/D IPT turret, with (8) B tooled, 16 mm diameter, 16 mm depth of fill and (8) D tooled, 25 mm diameter, 16 mm depth of fill stations in single turret, with additional 9 station IPT B toolded turrent, 42 Kn pre-compression, 65 Kn main compression, keyed upper punch guides, singled sided with force feeder, commission# 706849, built 2002.

  • At Natoli, we know that quality is paramount. Our cutting‐edge Precision CT Scan Service is designed to detect even the subtlest imperfections in tablets, ensuring you achieve the highest standards of quality every time.