INSIGHTS ON SOLID DOSE MANUFACTURING

• Overview Of Hot Melt Extrusion And Its Pharmaceutical Applications

  More than 40% of NCEs face aqueous solubility challenges. Here, we examine how hot melt extrusion addresses solubility, modified release, abuse deterrence, and scale-up across pharmaceutical development.

• Future-Proofing Aseptic Manufacturing

  Investing in adaptable aseptic manufacturing pays off. Find out how flexible systems, despite higher initial costs, handle complex drugs and changing volumes to boost productivity and quality.

• Overload Setting – Tricks And Techniques

  Learn how a partner company that is committed to assisting manufacturers with calibration and optimal set-point establishment can serve as a valuable resource in achieving optimal tablet production.

• HPAPI Containment: A Full Lifecycle Safety Innovation

  Containing highly potent APIs across a full operational lifecycle requires a structured approach that addresses hazard scoring, quality by design, performance testing, and safe enclosure disposal.

• Solubility Enhancement Via Amorphous Solid Dispersions

  2/27/2025

  Polyvinyl alcohol (PVA) is a versatile polymer platform used to enhance solubility through hot melt extrusion. Explore the role it plays in drug solubility, hydrolysis, and thermal behaviors.

• A Brief History Of Aseptic Processing

  3/27/2025

  From Bunsen burners to advanced isolators, aseptic processing has evolved significantly. Delve into the evolution of this crucial manufacturing method, from its early sterilization techniques to today's highly controlled and regulated environments.

• Improving Bioavailability Through Predictive Modeling Of Solubility Enhancement Strategies

  7/15/2026

  In silico modeling cut through formulation guesswork for a compound with 0.015 mg/mL solubility, delivering an 8× Cmax and 5× AUC improvement and Phase I progression.

• Innovations, Solutions, And USP <1062> With Scale Up

  11/4/2025

  Optimize tablet compression by simplifying calibration, speeding up changeovers, and utilizing advanced laser inspection to prevent critical punch tip wear and maintain quality.

• Overcoming The Obstacles Of Spray-Dried Dispersion Scale-Up

  9/9/2026

  SDD scale-up introduces scale-dependent risks that threaten bioavailability, stability, and manufacturability. This white paper details a model-based framework for managing those risks from early feasibility through commercial production.