INSIGHTS ON SOLID DOSE MANUFACTURING
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![GettyImages-1465073079-pills-coated]( "Modified Release Formulations: Extending Drug Commercial Lifecycle")
Modified Release Formulations: Extending Drug Commercial LifecycleA CDMO with expertise in modified-release dosage forms can provide valuable assistance in formulation development, processing considerations, analytical challenges, and regulatory requirements.
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![Natoli - Fundamentals Of Power Blending Simulations]( "Fundamentals Of Power Blending Simulations")
Fundamentals Of Power Blending SimulationsPredicting blending quality doesn't have to be a guessing game. Learn how to leverage virtual prototypes to make informed decisions and minimize costly trial-and-error in tablet manufacturing.
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![adare osd]( "Combining Powdose® And Diffucaps® For Precise Solid Oral Dosing")
Combining Powdose® And Diffucaps® For Precise Solid Oral DosingCombining POWDOSE® and Diffucaps® enables precise, individualized solid oral dosing—improving drug delivery, patient compliance, and therapeutic outcomes in personalized medicine applications.
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![Weight Loss_GettyImages-2123088969]( "Advancements In GLP-1 Analog Formulation: Overcoming Challenges")
Advancements In GLP-1 Analog Formulation: Overcoming ChallengesOral GLP-1 formulations represent a groundbreaking advance in obesity treatment to offer improved patient comfort and adherence while expanding the therapeutic market.
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Optimizing DPI Production: Filling Technologies For Precision And Performance4/16/2025
Developing effective dry powder inhalers requires expertise across multiple disciplines, from particle engineering and device technology to manufacturing science and regulatory knowledge.
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Less Mess, Less Stress, Best Expressed: An Alternative To Spray Drying7/16/2024
Although well-established processes, spray drying and hot-melt extrusion can be outperformed in bioavailability, cost-savings, manufacturing speed, environmental impact, and more.
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Solubility Enhancement Via Amorphous Solid Dispersions2/27/2025
Polyvinyl alcohol (PVA) is a versatile polymer platform used to enhance solubility through hot melt extrusion. Explore the role it plays in drug solubility, hydrolysis, and thermal behaviors.
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The Crucial Role Of Cleaning In Effective VPHP Decontamination For Isolators12/27/2024
Effective isolator cleaning is crucial for vapor phase hydrogen peroxide (VPHP) decontamination. Proper tools, techniques, and training ensure sterility, and regulatory compliance.
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Functional Release Multiparticulates Slam7/17/2024
Review Adare Pharma Solutions’ innovative technologies and learn how these capabilities can improve patient outcomes and improve manufacturing efficiency.
SOLID DOSE MANUFACTURING SOLUTIONS
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![flexiblecontainmentisolators]( "Flexible Containment Isolators")
Flexible Containment Isolators provide containment standards better than can be achieved with Downflow Booth technology, and often compare favorably with a Rigid Isolator system.
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![Dec 1]( "Loading And Charging Of Drums For High Potent API's: IsoTube")
Isotube is an effective option for the safe loading and charging of multiple drums of HPAPIs. Compared to the DCS® Drum Containment System for safely discharging drums, it is the preferred choice when charging lumpy and agglomerated products as a lump breaker system can be included in the lower part of the discharge hopper.
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![Filling of Powders into Drums and Bag]( "Filling Of Powders Into Drums And Bags")
Dec excels in providing comprehensive technical solutions for packing powders into bags and drums from process equipment discharge such as a dryer or a mixer, milling and dispensing to the final packing of the product.
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![GEA MM-PSR Spray Dryer]( "Used GEA Pharmaceutical Spray Dryer: MM-PSR")
Used GEA Mobile Minor Spray Dryer, Model MM-PSR, stainless steel construction, 0.8 meter diameter chamber, GEA Niro nozzle atomixer, cone bottom, with top expansion chamber, with inlet HEPA filter housing, cyclone fines collector, discharge filter housing, and .95 kw blower, control panel with Allen Bradley Panelview1500 HMI, project# 1093-2412, built 2017.
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![iStock-870087778-powder]( "Powder Flow Properties & Characterization Services")
Basic Powder Flow Characterization [USP <1174>]:
A powder flow analysis is an indicator of how well formulation will release from the hopper during the tableting. It is important to know that the developed formulation is showing ‘Mass Flow’ or ‘Funnel Flow’ or ‘Rat Holing’.
Powder blend shows ‘Mass Flow’ when the entire solid bed is in motion during the discharge of material from the outlet. This is a ‘First-in-First-Out’ process. Hoppers offering ‘Mass Flow’ have steep and/or low-friction walls. This flow offers ‘No-Arching’, ‘Less Segregation’, and ‘Stable Powder Flow’.
When the hopper is not sufficiently steep and smooth enough to ensure sliding along its wall, the powder blend exhibit ‘Funnel Flow’. Such hoppers are sensitive to arching and ratholing. In this case, powder discharge from the hopper is not predictable.
