INSIGHTS ON SOLID DOSE MANUFACTURING

SOLID DOSE MANUFACTURING SOLUTIONS

  • Establish safe barrier protection in minutes with a portable benchtop isolator. Secure containment for hazardous materials or inert gas processing across flexible laboratory scales.

  • Open RABS as a housing for aseptic processes, e.g., filling, loading, and unloading of freeze dryers. Product protection is achieved by a barrier (oRABS housing with gloves) between the operator and the product.

  • Used Korsch XL 400 2-Layer rotary tablet press. 35 station with B turret, 29 station with D turret. Serial# K1500036, built 2001.

  • Handling highly potent active pharmaceutical ingredients safely requires precise pressure control and automated breach response that many facilities struggle to maintain consistently.

  • When AST came to the table on the design for our new fill-finish isolator, one of the first areas AST engineers wanted to address was the usability and accessibility of the isolator and corresponding operations. With our customers’ point of view in mind, we wanted to address specific points of friction routinely encountered by operators and closely examine whether those friction points were necessary.

    Does an isolator need to be ergonomically unfriendly to clean?

    Should simple mechanisms like isolator doors be challenging to engage? (As much as one can appreciate exercise, no one wants to do “arm day” in cleanroom coveralls).

    Does routine maintenance have to be time-consuming and laborious?

    Many of these factors are accepted as par for the course in aseptic fill-finish manufacturing. Our question was, why?