INSIGHTS ON SOLID DOSE MANUFACTURING
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The Future Of Pharma Packaging Trends, Technologies, And Patient-Centric Solutions
Pharmaceutical packaging must evolve alongside drug development to ensure stability, safety, and regulatory adherence, utilizing innovative designs to improve therapeutic outcomes and patient accessibility.
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Pharmaceutical X-Ray Counts Capsules And Pills
See how advanced x-ray inspection technology verifies correct pill count, identifies broken capsules, and detects foreign contaminants in pharmaceutical sachet packets.
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A Simple And Powerful Solution For Accelerating Dissolution
Many poorly soluble drugs fail not because of low solubility, but because they dissolve too slowly. Learn how focusing on dissolution rate can unlock absorption gains using simple strategies.
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Global Regulatory Harmonization: Comparisons In Aseptic Barrier Systems
Compare global aseptic standards from the FDA, EMA, PIC/S, and WHO. Gain insights into how advanced barrier systems harmonize international requirements to ensure sterile product integrity and safety.
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Lower Punch Tip Bending / Buckling11/11/2024
When manufacturing mini-tablets, adjusting punch force ratings is crucial to prevent bending or buckling. The Rankine-Gordon formula offers a safer force rating for microtip tooling.
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How To Solve Complex Pediatric Dosing Challenges Using Tailored Solutions8/11/2025
With a partner who understands the science, the regulations, and the real-world demands of dosing children, development can move faster, smarter, and with greater confidence
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High Potency APIs And The Evolving Demands Of Drug Development4/13/2026
See how higher API activity is changing expectations around containment, scalability, and cross‑functional alignment — and why early decisions now have a greater impact on long‑term success.
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Improving API Solubility Using Hot Melt Extrusion Formulation2/27/2025
Solubility of active pharmaceutical ingredients (APIs) is a challenge in drug development. Discover how hot melt extrusion with polyvinyl alcohol enhances API solubility and stability to offer improved drug delivery.
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Solubility Enhancement Via Amorphous Solid Dispersions2/27/2025
Polyvinyl alcohol (PVA) is a versatile polymer platform used to enhance solubility through hot melt extrusion. Explore the role it plays in drug solubility, hydrolysis, and thermal behaviors.
SOLID DOSE MANUFACTURING SOLUTIONS
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Closed RABS as a housing for aseptic processes, e.g., filling, loading, and unloading of freeze dryers. Product protection is achieved through a barrier (cRABS housing with gloves) between the operator and the product.
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Partner with Natoli Scientific during the earliest stages. Our scientific expertise with state-of-the-art analytical capabilities is ready to take any preformulation challenge.
Natoli scientific has an expertise of handling a wide range of APIs for the development of oral solids. We apply principles of ‘Quality by Design’ to define Critical Material Attributes (CMA), Critical Process Parameters (CPP), Critical Quality Attributes (CQA) and Quality Target Product Profiles (QTPP). Because we believe that understanding material and process as much as possible in the early life cycle of drug product development program is an insurance for further development path. Keeping your practices up to date with the ICHQ8 regulatory guidance issued by the US FDA. This is also a gate way for a smooth ride of product in the different stages of product development stages.
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Unused 600 liter GEA high shear mixer, model PMA 600 Advanced, 316L stainless steel product contact surfaces, 240-450 liter working capacity, 36 kw main impeller, 1-170 rpm, 11 kw chopper, 1000-3000 rpm, jacketed bowl, machine designed to 16 bar shock rating, full vacuum rated bowl, 8" side discharge with valve, integrally mounted Quadro Comil, model U20, integrally mounted blade hoist, associated control systems with Allen Bradley plc and HMI designed for class 1 div 2 area, 480 volt, with GEA temperature control unit, model PMS 600, WIP design, through the wall design mounted on base with PL600 IBC hoist with (4) approximately 750 liter IBC's, PMA 600 Advanced serial# 14369.1310, built 2015 and unused.
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Ensure sterile compliance and safety by understanding proper airflow and pressure dynamics in your compounding workflow. Choose the right hardware for your facility.
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Dec has designed a wide range of versatile and low cost flexible containment solutions such as disposable glove bags, complete flexible enclosures and semi-rigid isolators suitable for many operations whether it be formulation plants including dispensing and granulation or around tablet pressing machines for both R&D and production facilities.