INSIGHTS ON SOLID DOSE MANUFACTURING

• Compaction Simulation For Tablet Technology Transfer And Scale-Up

  Compaction simulation de-risked tech transfer for a 40 mg fexuprazan tablet by defining optimal roller compaction and lubrication parameters before scale-up. Access the full case study to see the data.

• Predicting Softgel Stability And Shelf Life Using Accelerated Modeling

  Predict ibuprofen softgel shelf life in 21 days instead of years. ASAPprime modeling identified PEG-ester degradants as the limiting factor, estimating 5.5-year and 3.8-year shelf lives before long-term studies concluded.

• Predicting Drug-Loading Limits In Tablet Formulations

  Learn how predictive percolation modeling identified critical drug-loading limits of ~20% for crystalline API and ~15% for SDD forms, cutting tablet formulation trial-and-error significantly.

• Modeling Polymer Interactions To Improve Amorphous Solid Dispersion Stability

  Molecular dynamics modeling revealed how hydrogen bonding between PVP and Eudragit drives stable amorphous solid dispersion formation, cutting formulation screening time significantly.

• Enabling Complex Phase IIa Dosing Through Flexible Clinical Packaging Design

  5/6/2026

  Discover how flexible, patient‑centric clinical packaging supports complex Phase IIa dosing while protecting timelines, ensuring compliance, and avoiding costly primary packaging changes.

• Global Regulatory Harmonization: Comparisons In Aseptic Barrier Systems

  4/20/2026

  Compare global aseptic standards from the FDA, EMA, PIC/S, and WHO. Gain insights into how advanced barrier systems harmonize international requirements to ensure sterile product integrity and safety.

• Innovations, Solutions, And USP <1062> With Scale Up

  11/4/2025

  Optimize tablet compression by simplifying calibration, speeding up changeovers, and utilizing advanced laser inspection to prevent critical punch tip wear and maintain quality.

• Tablet Consistency And Punch Length – A Pragmatic Perspective For European Manufacturers

  10/7/2025

  Tablet consistency relies on a balance of formulation, press mechanics, and tooling. Learn why punch length tolerance is often overstated and what other critical factors truly drive quality and uniformity.

• Rheological Properties Of Pharmaceutical Excipients: Lactose Monohydrate And Carboxymethyl Cellulose

  12/30/2024

  Explore lactose monohydrate and CMC rheology, highlighting their flow, cohesion, and compressibility properties to optimize pharmaceutical formulations under varying stress and temperature conditions.