06.05.23 -- Antibody Variants, Mechanistic Modeling, And High-Throughput Process Development

This presentation shows how to develop an efficient downstream purification process for a cancer immunotherapy bispecific antibody (bsAb).

In this study, we looked at how different antibody binding sites of a Protein A ligand are affected by cleaning-in-place (CIP).

In this case study, we used mechanistic modeling to investigate how AAV-resin interactions are affected when MgCl₂ is used as an elution additive.

Discover a step-by-step high-throughput process development (HTPD) workflow to determine the optimal resin and initial conditions for hydrophobic interaction chromatography (HIC).