Change In Particle Size Of Immediate And Controlled Release Formulations
Source: Vector Corporation
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•Application Note: Change In Particle Size Of Immediate And Controlled Release Formulations
To study the particle size changes that occur during the water infusion and high shear (or wet-mass) phases of a wet granulation process.
•Application Note: Change In Particle Size Of Immediate And Controlled Release Formulations
•Application Note: Change In Particle Size Of Immediate And Controlled Release Formulations
To study the particle size changes that occur during the water infusion and high shear (or wet-mass) phases of a wet granulation process.
One immediate release (IR) and one controlled release (CR) formulation were used in this study. The granulations were made in a 600-liter high shear unit (Vector GMX-600). Mixer blade speed was 98 rpm for pre-mix and water infusion steps and 155 rpm for high-shear step. The chopper was run on high speed for the high-shear step. Samples were withdrawn after pre-mix, during water infusion, and during the high-shear phase. Each sample was dried with 65°C air using a fluid-bed dryer until the product was less than 2.5% moisture content. Sieve analyses were performed to determine the arithmetic mean diameters (D50) of the dried granules.
Click Here To Download:
•Application Note: Change In Particle Size Of Immediate And Controlled Release Formulations