Newsletter | October 4, 2019

10.04.19 -- Considerations For Application-Specific Enhancements Of Single-Use Bioreactors

 
SUB Enhancements For High-Density Perfusion Cultures
 

Progressive advances in media optimization and improved clone genetic selection have underscored the perceived performance limitations of single-use bioreactors (SUBs). This study presents how strategic enhancements to the sparge and agitation systems of SUBs have revealed the potential for a three- to four-fold improvement in mixing and mass transfer performance compared to legacy SUB designs.

Enhanced Single-Use Bioreactor Performance For Scalable Vero Cell Culture On Microcarriers In Serum-Free Medium
 

Adherent cell cultures, such as those with Vero cells, are often more challenging than their suspension-based counterparts with scale-up methods that require optimization of agitation and other operating parameters. This application note presents how single-use bioreactors (SUBs) can be enhanced for scaled-up growth of adherent cells on microcarriers in serum-free medium, in culture volumes of 50 L, 250 L, and 500 L.

Application Enhancements For The HyPerforma SUB
 

With many end users now demanding streamlined operations, high-density culture in fed-batch modes, even higher production by perfusion cultures, and contrastingly gentle operations required in microcarrier applications, standard SUB (single-use bioreactor) offerings must keep pace with the ever-evolving needs of the bioprocessing industry. Read about recent enhancements that are helping keep up with these increasing demands.

SUB Enhancements For High-Density Fed-Batch Cultures
 

As customers create increasingly demanding processes, legacy single-use bioreactors (SUBs) need modification to accommodate higher mixing and mass transfer, supporting higher oxygen demands in aggressive fed-batch cultures. This study presents how strategic enhancements of SUBs have improved mixing and mass transfer performance compared to legacy SUB designs.

Solution
A Next-Level Innovation In Single-Use Bioreactors: Unmatched Design, Scalability, And Performance
 

This single-use bioreactor was designed to accommodate modern cell culture processes and has features that will help you save time and costs and enable your bioprocessing and scale-up success. Watch this short video introduction to learn more.